RATIONALE The optimal therapeutic regimen for primary malignant melanoma of the esophagus (PMME) need to be further elucidated. Besides, the efficacy of surgery for PMME with remote metastasis is uncertain for its rarity. PATIENT CONCERNS Herein a previously healthy patient was admitted for dysphagia and fatigue, without significant weight loss. DIAGNOSES The pathological and molecular test...

BACKGROUND Esophageal carcinoma is a malignancy with a poor prognosis and new treatment modalities must be sought. One possibility that has been tested in patients with malignant melanoma is treatment which aims towards boosting the immune system. In the present study, we investigated the role of mast cells in patients with esophageal carcinoma. The intention was to determine whether a higher n...

Background: Malignant melanoma is the leading cause of death among skin cancers in western countries. However, the incidence, histologic subtypes, and tumor behaviors are quite different in Asians and western populations. Objective: This study was designed to survey the clinicopathological aspects of malignant melanoma among Khouzestan people. Patients and Methods: In a retrospective stud...

BACKGROUND There is no consensus whether firefighters are at increased cancer risk for particular cancers. Previous studies have been small, mostly investigated cancer mortality, and suggested increased risks for brain, bladder, testicular, prostate, thyroid and colo-rectal cancers, leukemia, and melanoma. METHODS Records of all male cancers registered in California during 1988-2003 were obta...

Primary malignant melanoma of the esophagus (PMME) is a rare disease, comprising 0.1-0.2% of all malignant esophageal neoplasms. The most common symptoms include progressive dysphagia, chest and back pain, choking feeling and weight loss. PMME cannot be definitely diagnosed from clinical symptoms or CT examination, but can be confirmed by histological examination or a pathological examination. ...

1. Ataxia Telangiectasia (includes Ataxia Telangiectasia 12 Complementation Groups A, C, D, E, Louis–Barr Syndrome) 2. Basal Cell Nevus Syndrome, Nevoid Basal Cell 18 Carcinoma Syndrome, or Gorlin Syndrome 3. Beckwith–Wiedemann Syndrome 19 (Exomphalos–Macroglossia–Gigantism Syndrome) 4. Birt–Hogg–Dubé Syndrome 20 5. Bloom Syndrome 21 6. Breast/Ovarian Cancer, Hereditary (BRCA1) 22 7. Breast/Ova...

A 48-year-old man presented with retrosternal pain after eating. This problem had persisted for about 7 days. The pain typically disappeared within a few minutes but recurred every time the patient tried to eat. No dysphagia, hematemesis, melena, or weight loss was observed. Upon esophagoscopy, several black lesions were observed. They were scattered throughout the middle esophagus (Fig. 1A). P...

although gastrointestinal involvement by metastatic malignant melanoma is common but primary gastrointestinal (gi) melanoma has been reported in rare cases. in this study we report two cases of primary gastrointestinal malignant melanoma that one of them is a known case of neurofibromatosis type 1(nf1). both cases showed no evidence of any lesions in skin and eye. malignant melanoma of gi tract...

in order to distinguish between benign and malignant types of pigmented skin lesions, computerized procedures have been developed for images taken by different equipment that the most available one of them is conventional digital cameras. in this research, a new procedure to detect malignant melanoma from benign pigmented lesions using macroscopic images is presented. the images are taken by co...

malignant melanoma is a potentially aggressive tumor of melanocytic origin. primary oral malignant melanoma is a rare neoplasm, accounting for 0.5% of all oral malignancies. the present case occurred in a 60‑year‑old female patient, as a pedunculated growth involving the palate and alveolar ridge and histologically showing a desmoplastic differentiation. the article discusses the distinct clini...