Objective(s):Cytochrome P-450 1A1 is an important enzyme in the first phase of the metabolism of some carcinogens such as polycyclic aromatic hydrocarbons (PAHs), as well as estrogen. The present study evaluates the existence of CYP1A1 polymorphism in a number of breast cancer samples. Materials and Methods: One hundred breast cancer patients and the same number of healthy controls were analyz...

Stearoyl-CoA desaturase (SCD) is a rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids (MUFA). A number of studies support the hypothesis that SCD gene regulation and polymorphism may affect fatty acid composition and fat quality in meat and milk. Single nucleotide polymorphisms in the coding region of the bovine stearoyl-CoA desaturase gene have been predicted to result in ...

background: several studies showed that elevated plasma homocysteine level is a risk factor for coronary artery disease (cad). a common polymorphism c677t of methylenetetrahydrofolate reductase (mthfr) gene is reported to be associated with decreased enzyme activity and increased blood homocysteine level. methods: this study evaluated the association between c677t polymorphism and blood homocys...

converting enzyme I/D polymorphism and hypertension: the Ohasama Humphries SE, Montgomery HE. Severity of meningococcal disease study. J Hypertens 2002;20:1121–1126. in children and the angiotensin-converting enzyme insertion/deletion 5. Feng Y, Niu T, Xu X, Chen C, Li Q, Qian R, Wang G, Xu X. Insertion/ polymorphism. Am J Respir Crit Care Med 2002;165:1103–1106. deletion polymorphism of the AC...

an attempt has been made to analyze the distribution of the beta-lactoglobulin genotype in swamp buffaloes and murrah buffaloes utilizing polymerase chain reaction-restriction fragment length polymorphism(pcr-rflp). blood samples were taken from 50 swamp buffaloes and 50 murrah buffaloes. the dna was extracted by the phenol-chloroform method. the pcr-rflp was performed using beta-lactoglobulin ...

angiotensin converting enzyme (ace; omim: 106180) has an important role in the conversion of angiotensin i to angiotensin ii and degradation of bradykinin. genetic polymorphism i/d (rs4646994) in the gene encoding ace has been well defined. to get more insight into the genetic structure of iranian populations, the distribution of the ace i/d polymorphism among iranians was compared with each ot...

the objective of the present study was to detect polymorphism in follicle stimulating hormone receptor (fshr) and beta subunit of follicle stimulating hormone (fshβ) genes and their relation to litter size and body weight trait in baluchi, iran black and arman sheep breeds. pcr-rflp technique using acci and hinfi enzyme treatments employed to detection of polymorphism in fshβ marker site but de...