Ollier's disease also known as enchondromatosis is a rare skeletal disorder that is usually sporadic, non-hereditary, and characterized by abnormal bone development (skeletal dysplasia). While this disorder may be present at birth (congenital); it may not become apparent until early childhood with more obvious symptoms, such as deformities or improper limb growth. It carries high risk of skelet...

We report four patients who showed hundreds of brilliant white loose bodies at arthroscopy of the knee after a short history of pain and crepitus. Histological, historical and clinical evidence is presented which indicates that the aetiology of this condition is the culture of chondrocytes in synovial fluid. It is suggested that reversal of the usually accepted order of events in synovial osteo...

We present 12 patients with synovial osteochondromatosis of the elbow treated by synovectomy. Histological review showed that seven cases were primary and five secondary osteochondromatosis. The patients with primary disease had a mean improvement in the flexion arc from a preoperative value of 40 degrees to 123 degrees to 5 degrees to 128 degrees when reviewed at a mean of nine years after ope...

Ollier disease, also known as multiple enchondromatosis, is a rare congenital disease of unknown etiology. The main manifestation this non‑ossifying chondrocyte mass or hamartomatous growth in the metaphysis. A few cases can develop into chondrosarcoma osteosarcoma. present study describes case 37‑year‑old male patient with left hip pain and dyskinesia diagnosed according to clinical features f...

We present a 25-year-old male patient with a diagnosis of multiple enchondromatosis, who developed chondrosarcoma on the proximal humerus of the right upper limb. The patient had the pre-existing lesions of Ollier's disease discovered during his childhood. The patient underwent wide resection of the sarcoma with a prosthetic replacement of the proximal humerus. So far we have followed up the pa...

Please cite this article as: León FM, Gómez Quiroz C, Zernotti ME. Encondroma de mastoides secundario a encondromatosis generalizada. Acta Otorrinolaringol Esp. 2014;65:271--272. ∗ Corresponding author. E-mail address: [email protected] (M.E. Zernotti). generalised chondromatosis (Fig. 1). The patient’s right leg had been amputated as an infant. Physical examination revealed deformity of...

Endochondral bone development is a fascinating story of proliferation, maturation, and death. An understanding of this process at the molecular level is emerging. In particular, significant advances have been made in understanding the role of parathyroid-hormone-related peptide (PTHrP), parathyroid hormone (PTH), and the PTH/PTHrP receptor in endochondral bone development. Mutations of the PTH/...