Haseman & Elston (1972) introduced a sib pair method using classical regression analysis to detect linkage between a polymorphic marker locus and any quantitative trait locus. Most of the diseases mapped to date follow simple Mendelian, single locus transmission. But there are many familial diseases that do not follow simple Mendelian segregation, for example diabetes, several forms of cancer, ...

Selection of high yielding genotypes to be carried over to subsequent selection cycles in a breeding programme can sometimes be accomplished using a suitable index of secondary traits that may be relatively less sensitive to genotype-by-environment interactions than yield. We used the concept of correlated response to selection to measure the relative efficiency of nine selection indices. The r...

Measurement of parasternal intercostal EMG during an infective exacerbation in patients with Cystic Fibrosis Authors Charles C Reilly, Caroline J Jolley, Caroline Elston, John Moxham & Gerrard F Rafferty Affiliations King’s College London, UK. King’s College Hospital NHS Foundation Trust, London UK. Corresponding author Charles Reilly, King’s College London, Division of Asthma, Allergy and Lung...

Various algorithms have been developed for variant calling using next-generation sequencing data, and various methods have been applied to reduce the associated false positive and false negative rates. Few variant calling programs, however, utilize the pedigree information when the family-based sequencing data are available. Here, we present a program, FamSeq, which reduces both false positive ...

En la actualidad producción de quinua está limitada principalmente por falta variedades que tengan alto rendimiento con granos grandes, posean madurez uniforme y sean precoces bajo las condiciones edafoclimáticas del altiplano. La investigación selección líneas obtenidos hibridación, se realizó el objetivo seleccionar promisorias a partir autofecundaciones S5 cruzas simples una presión genética...

We propose a general likelihood-based approach to the linkage analysis of qualitative and quantitative traits using identity by descent (IBD) data from sib-pairs. We consider the likelihood of IBD data conditional on phenotypes and test the null hypothesis of no linkage between a marker locus and a gene influencing the trait using a score test in the recombination fraction theta between the two...

Parametric linkage methods for quantitative trait locus mapping require explicit specification of the probability model of the quantitative trait and hence can lead to misleading linkage inferences when the model assumptions are not valid. Ghosh and Majumder developed a nonparametric regression method based on kernel-smoothing for linkage mapping of quantitative trait locus using squared differ...