An alcoholic extract of Biophytum sensitivum was studied for its immunomodulatory and antitumor activity. The extract was 100% toxic at a concentration of 0.5 mg/ml to Dalton's lymphoma ascites (DLA) and Ehrlich ascites carcinoma (EAC) cells. B. sensitivum extract was also found to be cytotoxic towards L929 cells in culture at a concentration of 0.1 mg/ml. Administration of B. sensitivum extrac...

The proline-rich peptide (PRP-1) isolated from neurosecretory granules of the bovine neurohypophysis, produced by N.supraopticus and N.paraventricularis, has many potentially beneficial biological effects. PRP-1 been shown to have opposite effects on cell death in neurodegenerative cancer diseases. It significantly reduces staurosporine-induced apoptosis postnatal hippocampal cells, as well dox...

The immunological response of mice given implants of Ehrlich ascites carcinoma was modified as evidenced by the failure of ascitic mice to reject primary or secondary skin homografts or rat skin heterografts. The site of tumor implantation influenced its effect on the host, since subcutaneously implanted Ehrlich ascites carcinoma did not alter the immune response. The presence of the tumor in t...

Macromomycin (MCR) is a polypeptide antimuor antibiotic isolated from the culture broth of Streptomyces macromomyceticus. Antitumor activities of MCR were examined against three different tumor system, i.e., EHRLICH ascites carcinoma, L1210 leukemia and LEWIS lung carcinoma. Daily intraperitoneal treatment with MCR for 5 days showed a strong inhibition against EHRLICH ascites carcinoma. Both si...

The effects of the synthetic estrogens diethylstilbesterol, hexosterol, dienesterol, and phloretin were compared with their capacity to inhibit the endogenous respiration of intact Ehrlich ascites, Adenocarcinoma 755 ascites, and Ehrlich-Lettr6 ascites cells. The Ehrlich ascites was found to be far more susceptible to respiratory inhibition than either the Adenocarcinoma 755 or the Ehrlich-Lett...

The antitumor activity of anti-infective drugs containing iodine complex with bio-organic ligands and potassium and lithium halides (LiCl (I)I2-a-dextrin-peptide) has been experimentally studied. It is shown that the combined action of the drug containing LiCl (I)I2-a-dextrin-peptide complexes and doxorubicin on the growth of Ehrlich ascites carcinoma (EAC) significantly enhanced the antitumor ...

The creatine/creatine kinase system decreases drastically in sarcoma. In the present study, an investigation of catalytic activities, western blot and mRNA expression unambiguously demonstrates the prominent expression of the creatine-synthesizing enzymes l-arginine:glycine amidinotransferase and N-guanidinoacetate methyltransferase in sarcoma, Ehrlich ascites carcinoma and Sarcoma 180 cells, w...

A number of novel 3-bromo-4-methyl-7-methoxy-8-amino substituted coumarins and 2-substituted 7-bromo-6-methyl-8H-pyrano-benzimidazoles, benzoxazoles and/or benzoxazine-8-ones were synthesized for the purpose of pharmacological evaluation. Some representative compounds showed antitumor activity in vitro on Ehrlich ascites carcinoma in the preliminary testing.