نتایج جستجو برای: e4

تعداد نتایج: 3623  

Journal: :Circulation. Cardiovascular genetics 2011
Puneetpal Singh Mario Di Napoli Monica Singh

BACKGROUND In humans, the E4 allele of the apolipoprotein E gene is associated with increased coronary heart disease risk. Surprisingly, in rodents, apolipoprotein E4 only accelerates the atherosclerotic process when transgenic for the human low-density lipoprotein receptor (LDLR) protein. We therefore investigated whether the LDLR locus interacted with the apolipoprotein E gene genotype on cor...

2016
Ekaterine Tskitishvili Christel Pequeux Carine Munaut Renaud Viellevoye Michelle Nisolle Agnes Noël Jean-Michel Foidart

Estetrol (E4), estradiol (E2) and progesterone (P4) have important antioxidative and neuroprotective effects in neuronal system. We aimed to study the consequence of combined steroid therapy in neonatal hypoxic-ischemic encephalopathy (HIE). In vitro the effect of E4 combined with other steroids on oxidative stress and the cell viability in primary hippocampal cultures was evaluated by lactate ...

Journal: :modares journal of medical sciences: pathobiology 2012
fatemeh motevalli arash memarnejadian seyed mehdi sadat golnaz bahramali farzin roohvand

objective: animal studies show that vaccination with epitope-based peptides results in protective immunity. however, immunodominance should be regarded as a major challenge in this area. considering the advantages of epitopic-vaccines against hepatitis c virus (hcv) infection, herein, we compared the occurrence of immunodominance following mice immunization with three different hcv epitopic-pep...

Journal: :Journal of neurology, neurosurgery, and psychiatry 2002
M J A Robson R P Alston P J D Andrews P R Wenham M J Souter I J Deary

The apolipoprotein E (apoE) gene (APOE) is polymorphic with three alleles, e2, e3, and e4, which give rise to three isoforms, E2, E3 and E4. Many reports have now described a strong association between the e4 allele and risk of developing late onset Alzheimer's disease as the result of the E4 isoform binding to β-amyloid protein and accelerating the depo-sition of amyloid, which is the main con...

Journal: :Journal of virology 2015
Kathleen Kong Manish Kumar Midori Taruishi Ronald T Javier

UNLABELLED The E4-ORF1 protein encoded by human adenovirus stimulates viral replication in human epithelial cells by binding and activating cellular phosphatidylinositol 3-kinase (PI3K) at the plasma membrane and cellular Myc in the nucleus. In this study, we showed that E4-ORF1 hijacks the tyrosine kinase activities of cellular epidermal growth factor receptor (EGFR) and insulin receptor (InsR...

2017
Nagayasu Egawa Qian Wang Heather M Griffin Isao Murakami Deborah Jackson Radma Mahmood John Doorbar

To clarify E1^E4's role during high-risk HPV infection, the E4 proteins of HPV16 and 18 were compared side by side using an isogenic keratinocyte differentiation model. While no effect on cell proliferation or viral genome copy number was observed during the early phase of either virus life cycle, time-course experiments showed that viral genome amplification and L1 expression were differently ...

Journal: :BMJ 1991
M Laakso A Kesäniemi K Kervinen M Jauhiainen K Pyörälä

OBJECTIVES To examine the relation between coronary heart disease and the apolipoprotein E phenotypes in patients with non-insulin dependent diabetes mellitus. DESIGN Cross sectional study. SETTING District around Kuopio University Central Hospital, East Finland. SUBJECTS 138 men with non-insulin dependent diabetes and 64 men without diabetes as controls. MAIN OUTCOME MEASURE Apolipopro...

Journal: :Neurobiology of aging 2012
Fumihiko Yasuno Satoshi Tanimukai Megumi Sasaki Chiaki Ikejima Fumio Yamashita Chiine Kodama Shin Hidaka Katsuyoshi Mizukami Takashi Asada

We examined the combined effect of plasma lipids/hypertension and apolipoprotein E (APOE) genotype on cognitive function in elderly individuals. Plasma concentrations of high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride (TG), total cholesterol (TC), APOE, and history of hypertension were evaluated in 622 community-dwelling individuals aged 65 years and older. We invest...

Journal: :The EMBO journal 1997
M Dobbelstein J Roth W T Kimberly A J Levine T Shenk

The E1B 55-kDa and E4 34-kDa oncoproteins of adenovirus type 5 (abbreviated here as E1B-55kD and E4-34kD) promote the export of viral mRNA and inhibit the export of most cellular mRNA species. We show that the intracellular complex containing E1B-55kD and E4-34kD continuously shuttles between the nucleus and the cytoplasm, and may thus serve as a nucleocytoplasmic transporter for viral mRNA. We...

Journal: :Nucleic acids research 2004
Elham S Mohammadi Elizabeth A Ketner David C Johns Gary Ketner

The human adenovirus E4 ORF 6 34 kDa oncoprotein (E4 34k), in concert with the 55 kDa product of E1b, prevents concatenation of viral genomes in infected cells, inhibits the repair of double strand breaks (DSBs) in the viral genome, and inhibits V(D)J recombination in a plasmid transfection assay. These activities are consistent with a general inhibition by the E4 34k and E1b 55k proteins of DS...

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