Chloride intracellular channel (CLICs) proteins show 60-70% sequence identity to each other, and exclusively localize to the intracellular organelle membranes and cytosol. In support of our recent publication, "Molecular identity of cardiac mitochondrial chloride intracellular channel proteins" (Ponnalagu et al., 2016) [1], it was important to characterize the specificity of different CLIC para...

The CLIC machine incorporates a 20 mrad crossing angle at the IP to aid the extraction of spent beams. In order to recover the luminosity lost through the crossing angle a crab cavity is proposed to rotate the bunches prior to collision. The crab cavity is chosen to have the same frequency as the main linac (11.9942 GHz) as a compromise between size, phase stability requirements and beam loadin...

A high luminosity (1034 1035 cm2/s) electron-positron Collider (CLIC) with a nominal centreof-mass energy of 3 TeV has been under study for a number of years in the framework of an international collaboration of laboratories and institutes, with the aim to provide the HEP community with a new facility for the post-LHC era. After a brief description of a CLIC scheme to extend Linear Colliders in...

This working paper is part of a series documenting communication, learning and information exchange between poor communities, municipal and state governments, and non governmental organisations in India. The series itself is one of the outputs of a two-year action research project funded by the British Government Department for International Development (DFID), Infrastructure and Urban Developm...

Chaining Layered Integrity Checks William A. Arbaugh Jonathan M. Smith \Dover y, no Prover y" “Trust, but Verify”1 In a system, the integrity of lower layers is typically treated as axiomatic by higher layers. Under the presumption that the hardware comprising the system (the lowest layer) is valid, the integrity of a layer can be guaranteed if and only if: (1) the integrity of the lower layers...

CLIC is a linear ee (γγ) collider project which uses a drive beam to accelerate the main beam. The drive beam provides RF power for each corresponding unit of the main linac through energy extracting RF structures. CLIC has a wide range of center-of-mass energy options from 150 GeV to 3 TeV. The present paper contains optimization of Free Electron Laser (FEL) using one bunch of CLIC drive beam ...

The determination of the smuon mass at the Clicmulti-TeV ee linear collider has been studied for two CMSSM benchmarks. Results are given for both the analysis of the muon energy spectrum and the threshold scan method. The effects of detector resolution, beam-beam interactions and accelerator-induced backgrounds are discussed. The energy spectrum technique is also applied to the t̃ → tg̃ process t...

In this paper, we review the role of a multi-TeV ee linear collider to complete the mapping of the Higgs boson profile and studying heavier bosons in extended scenarios with more than one Higgs doublet.

The main effects which limit accelerating gradient in CLIC (Compact Linear Collider) main linac accelerating structures are RF breakdown and pulsed surface heating. Recent highlights of the structure development program are presented, including demonstration of higher accelerating gradients using tungsten and a complete redesign of the CLIC main linac accelerating structure, based on reduced su...

The CLIC (Compact Linear Collider) RF power source is based on a new scheme of electron pulse compression and bunch frequency multiplication, in which the drive beam time structure is obtained by the combination of electron bunch trains in isochronous rings. The next CLIC Test Facility (CTF3) at CERN will be built in order to demonstrate the technical feasibility of the scheme. It will also con...