AIM To determine the association between HLA-DRB1 haplotypes and risk of cervical cancer in unselected and samples from Chinese ethnicities. METHODS A comprehensive search for articles from their inception to April 1st, 2013 was conducted from PubMed, Medline, Elsevier Science, Springer Link, Cochrane Library database, China biology medical literature database (CBM),China National Knowledge I...

HLA DRB1, DQA1 and DQB1 alleles were determined by DNA PCR-SSO typing in a sample of 99 individuals originating from Wielkopolska (midwestern Poland). A high number of alleles (38 DRB1, 8 DQA1 and 14 DQB1) was detected at each locus, many of them presenting notable frequencies in this population. The three HLA loci are thus characterized by very high heterozygosity levels (93% for DRB1, 85% for...

Of 957 patients with type 1 diabetes without known Addison's disease 1.6% (n = 15) were positive for 21-hydroxylase autoantibodies. Among DQ8/DQ2 heterozygous patients, the percentage expressing 21-hydroxylase autoantibodies was 5% (10 of 208) vs. less than 0.5% of patients with neither DQ8 nor DQ2. Three of the diabetic patients found to have 21-hydroxylase autoantibodies on screening were sub...

OBJECTIVE Type 1 diabetes mellitus (T1D) is an autoimmune and multifactorial disorder. Subsequent analysis on human leukocyte antigen ( HLA) region shows that HLA-DRB1 and -DQB1 genes have the strongest association with T1D. In this study, for the first time, we investigated the influence of gender on the HLA-DRB1 and -DQB1 association with type 1 diabetes mellitus in Iranian patients in order ...

OBJECTIVE The identification of a vitamin D-responsive (VDRE) motif within the HLA-DRB1*15:01 promoter region provides an attractive explanation for the combined effects of HLA-DR inheritance and vitamin D exposure on multiple sclerosis (MS) risk. We therefore sought to incorporate HLA-DRB1 promoter variation, including the VDRE motif, in an assessment of HLA-DRB1-associated MS risk. METHODS ...

multiple sclerosis (ms) is an inflammatory demyelinating disease of the central nervous system. it is a clinically heterogeneous disorder especially in terms of disease severity. current investigations suggest that genes and gene-gene interactions not only influence on susceptibility to ms but also affect the disease severity. in this study, we investigated the contribution of the hladrb1*1501 ...

Background Host genetic factors are the major determining factor for variation in response to HIV infection and are related to resistance among HIV patients. HLA dRB1*1501, DRB1*1502, DRB1*1301, DRB1*1302, DRB1*1101-05 are widely reported alleles associated with low viraemia in infected individuals. Computational predictions have made it possible to identify potentially strong peptide binders t...

Pemphigus Vulgaris (PV) has one of the strongest known HLA disease associations. The majority PV patients studied carry either DRB1*0402 or DQB1*0503. However, studies on associations in have largely focused populations with specific ethnic backgrounds, often Ashkenazi Jewish (AJ) and non-Jewish Caucasians there are limited African descent. We investigated status 11 American (AA) comparison to ...

OBJECTIVES To elucidate the contribution of HLA-DR-DQ haplotypes and their genotypic combinations to susceptibility to rheumatoid arthritis, and to evaluate the various models for HLA associated risk for the disease in a series of Finnish patients. METHODS 322 Finnish patients with rheumatoid arthritis were typed for common north European HLA-DR-DQ haplotypes and compared with a series of 124...