Recognition of the molecular mechanisms of cAMP action against DNA damage-induced apoptosis can be useful to improve the efficacy of DNA damaging therapeutic agents. Considering the critical role of bcl-2-associated death promoter (BAD) and p53 proteins in DNA damage -induced apoptosis, the aim of this study was to assess the effect of cAMP-elevating agents on these proteins in doxorubicin-trea...

background: in the past 20 years, a dramatic improvement in the prognosis of patients with hepatoblastoma (hb)has been achieved by combining surgery and chemotherapy in several national and international trials.materials and methods: four children ( 3 girl and 1 boy) aged 34 days, 4 months, 13 months, and 1 year with meanage of 6.53 (±5.15) months were presented to our center from 2002 to 2009 ...

Abstract: Background: Colorectal cancer (CRC) has grown to be the world’s fourth-biggest cause of cancer-related mortality. It is critical identify more effective treatment options for it. Objectives: Doxorubicin a potent antineoplastic agent widely used but severe adverse effects. Therefore, our objective use cubosome as an efficient drug delivery system reduce off-target effects and increase ...

abstract        background and objective: doxorubicin (dox) is an effective anticancer drug. it has been shown that  a short-term exercise performed prior to dox-treatment has no effect on cardiotoxicity in young rats. in the present study, old and young rats were evaluated to determine the protective effects of pre-treatment with short-term exercise on dox-induced oxidative damage in cardiac t...

hormone-independent prostate cancer cell lines are resistant to antineoplastic drugs, this study sought to determine the usefulness of lithium chloride as an inhibitor of glycogen synthase kinase-3β to increase the cytotoxic effect of doxorubicin, etoposide or vinblastine antineoplastic drugs on du145 cells. combination effect was assessed by using low and ic50 doses of drugs + lithium chloride...

abstract background: doxorubicin is used in treatment of many solid malignancies and lymphomas with poorly understood mechanism underlying tissue injury. rosemary leaves or extracts were found to contain high antioxidant activity almost equivalent to bha (butylated hydroxy anesole) and bht (butylated hydroxy toluene). thus, the possibility of aqueous rosemary leaves extract (re) to ameliorate d...

Abstract Doxorubicin, sold under the brand name Adriamycin among others, is an important drug for cancer therapy; however, its use limited by cardiotoxicity. Ginsenoside Rg2 extracted from Panax ginseng C.A.Mey., Araliaceae, which believed to have cardioprotective properties. However, date, there been no reports on whether ginsenoside could protect cardiomyocytes against doxorubicin. In this st...

doxorubicin (dox) is an anthracycline antibiotic that has been used for a long time in therapy of an array of human malignancies either alone or in combination with other cytotoxic agents. the dose-dependent cardiotoxicity of dox significantly limits its anticancer efficacies. oxidative stress caused by enhanced production of reactive oxygen species is an important contributor to dox mitochondr...

background: magnetic nanoparticles in a variable magnetic field are able to produce heat. this heat (42-45°c) has more selective effect on fast dividing cancer cells than normal tissues. methods: in this work magnetite nanoparticles have been prepared via co-precipitation and phase identification was performed by powder x-ray diffraction (xrd). magnetic parameters of the prepared nanoparticles ...