This randomized, double-blind, placebo-controlled study assessed the safety, tolerability, and plasma-kinetic behavior of 94% pure crystalline epigallocatechin gallate (EGCG) after ten days' repeated dosing in 36 healthy male volunteers. Each of the three treatment groups consisted of 12 subjects; nine of them received oral EGCG in one dose of 200, 400, or 800 mg daily, and three received a pla...

Various possible models of carcinogenesis are analyzed with respect to low dose kinetics. The importance of background carcinogenesis upon the shape of the dose-response curve at low dose is emphasized. It is shown that, if carcinogenesis by an external agent acts additively with any already ongoing process, then under almost any model the response will be linear at low dose. Measures of the de...

PURPOSE The objective was to determine whether optically stimulated luminescent dosimeters (OSLDs) were appropriate for in vivo measurements in high dose rate brachytherapy. In order to make this distinction, three dosimetric characteristics were tested: dose linearity, dose rate dependence, and angular dependence. The Landauer nanoDot™ OSLDs were chosen due to their popularity and their availa...

Background: Over recent decades, modern protocols of external beam radioÂ‌therapy and radiation techniques such as intensity-modulated radiotherapy (IMRT) have been developed. These methods are extremely sensitive to errors in treatment delivery, so that it is essential to apply a high resolution 3D dosimetry system that has high sensitivity and is capable of measuring and verifying the complex...

We have reviewed quality control testing of dose calibrators and have analyzed the potential for error. The uncertainty in half-lives of reference sources can lead to inaccurate assessment of the accuracy and constancy in dose calibrator performance. Molybdenum-99 contamination of '"Tc used as a reference source can appear as a nonlinear response of the dose calibrator. The useful life of a ref...

The shape of the dose-response relation between particulate matter air pollution and mortality is crucial for public health assessment, and departures of this relation from linearity could have important regulatory consequences. A number of investigators have studied the shape of the particulate matter-mortality dose-response relation and concluded that the relation could be adequately describe...

This study assessed the relationship between dose and plasma concentration following administration of treprostinil sodium infusion therapy in pulmonary arterial hypertension patients. This was a multicenter, open-label, multiple-cohort, steady-state, pharmacokinetic study in subjects with pulmonary arterial hypertension receiving treprostinil by continuous intravenous or subcutaneous infusion ...

BACKGROUND There is considerable evidence of the favourable role of more physical activity (PA) in fighting against dementia. However, the shape of the dose-response relationship is still unclear. OBJECTIVE To quantitatively investigate the relationship between dementia and PA. DESIGN PubMed, EMBASE, Ovid and the Cochrane Library were searched for prospective studies published from 1 Januar...