PURPOSE This study describes the development and validation of dissolution tests for fexofenadine hydrochloride capsules and coated tablets using an HPLC method. METHOD The appropriate conditions were determinate after testing sink conditions, dissolution medium, and agitation intensity. The apparatus, paddle and basket, were applied to tablets and capsules, respectively. Fexofenadine hydroch...

The present work concerns with an investigation on the solubility of cis,cis-muconic acid dissolution in different polar solvents by characterizing and modeling the dissolution as a function of temperature. Water, ethanol, 2-propanol and acetic acid have been investigated as solvents in the range temperatures from a 298.15 to 348.15 K. Owing to the absence of cis,cis-muconic acid solubility...

The aim of this study was to develop a novel microbially triggered and animal-sparing dissolution method for testing of nanorough polysaccharide-based micron granules for colonic drug delivery. In this method, probiotic cultures of bacteria present in the colonic region were prepared and added to the dissolution media and compared with the performance of conventional dissolution methodologies (...

The orally disintegrating tablet (ODT) is a novel dosage form that disintegrates in the oral cavity using saliva as the disintegrating medium and is swallowed as a fine dispersion. Due to rapid disintegration, the dissolution rate is controlled by the intrinsic solubility of the API; therefore, it is difficult to evaluate the effect of formulation and processing parameters on in vitro drug rele...

Heterogamous marriages, in which partners have dissimilar attributes (e.g. by socio-economic status or ethnicity), are often at elevated risk of dissolution. We investigated the influences of heterogamy by religion and area of residence on risk of marital dissolution in Northern Ireland, a country with a history of conflict and residential segregation along Catholic-Protestant lines. We expecte...

the solubility enhancement of poorly soluble compounds is an important task in pharmaceutical technology as it leads to better bioavailability and a more efficient application. fused dispersions (fds) of simvastatin (sim) using peo-ppo block copolymer were prepared which paved the way for the formation of an amorphous product with enhanced dissolution and bioavailability. the accumulative solub...

Diosmin, a vascular-protecting agent, is practically insoluble in water, and its oral absorption is limited by its extremely low dissolution rate. In this study, β-cyclodextrin (βCD) and 2-hydroxypropyl-β-cyclodextrin (HPβCD) were obtained to improve the solubility and dissolution rate of diosmin. Phase solubility studies of diosmin with βCD and HPβCD in distilled water were conducted to charac...

This study presents improvement in solubility and dissolution rate of valsartan (VAL) using β-cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HP-βCD). Formation and characterization of solid inclusion complexes were investigated by DSC, FTIR, SEM, HNMR and in-vitro dissolution studies. Preparation method influenced physical properties of binary mixtures. Inclusion complexes obtained by co-...

INTRODUCTION Dissolution testing is an in vitro technique of great importance in formulation and development of pharmaceutical dosage forms,as it can be used as a substitute for in vivo studies under strictly defined and specified conditions (1). For the comparison of in vitro dissolution data and for use of such data for in vivo bioequivalence testing and in vitro-in vivo correlations (IVIVC) ...

     Ibuprofen solid dispersions were prepared by the solvent and fusion-solvent methods using polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), eudragit RS PO, eudragit RL PO and hydroxypropylmethylcellulose (HPMC) as carriers to improve physicochemical characteristics of ibuprofen. The prepared solid dispersions were evaluated for the flowability, solubility characteristics and dissoluti...