The ethoxycarbonylmethyl esters of 1,4-dihydropyridines were directly converted into carbamoylmethyl esters in the presence of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) in good to excellent yields under mild conditions. The use of TBD is crucial for the successful aminolysis of ethoxycarbonylmethyl ester of 1,4-dihydropyridines with secondary amines as without it the reaction does not proceed a...

Gold(I)-catalyzed nucleophilic allylations of pyridinium and quinolinium ions with various allyl pinacolboronates are reported. The reactions completely selective respect to the site azinium ion that is attacked, give functionalized 1,4-dihydropyridines 1,4-dihydroquinolines. Evidence suggests proceed through allylgold(I) intermediates formed by transmetalation from allylboronates. Density func...

The classical Hantzsch reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful 1,4-dihydropyridine derivatives. Bismuth nitrate pentahydrate under microwave irradiation is proven to act as a very efficient catalyst for a one-pot, three-component synthesis of 1,4-dihydropyridines in excellent yields from diverse amines/...

Hantzsch 1, 4-dihydropyridines (1,4-DHPs) can be oxidized to the corresponding pyridine derivatives by thallium triacetate in high yields.

1,4 dihydropyridines (e.g. nifedipine) undoubtedly are among the most powerful calcium antagonists. They act by blocking Ca channels when bound from the outside of the sarcolemma on a proteinic receptor (Glossmann et al. 1982). From inotropic measurements it had been supposed that a new dihydropyridine compound (BAY-K 8644, Methyl

Previous studies have suggested the presence of different types of calcium channels in different regions of stomatogastric neurons. We sought to pharmacologically separate these calcium channel types. We used two different preparations from different regions of stomatogastric neurons to screen a range of selective calcium channel blockers. The two preparations were isolated cell bodies in cultu...