نتایج جستجو برای: dickkopf
تعداد نتایج: 961 فیلتر نتایج به سال:
Administration of iodinated contrast medium (CM) during invasive cardiovascular procedures may be associated with impairment kidney function. Urinary dickkopf-3 (DKK3), a stress-induced renal tubular epithelium–derived glycoprotein, has been identified as biomarker predicting both acute injury (AKI) and persistent dysfunction. DKK3/creatinine ratio (uDKK3/uCr), urine serum neutrophil gelatinase...
Recently, an inverse role for Wnt signaling in the development of osteoclasts in the bone was demonstrated. In the present study, we examined whether there is a commonality in the mechanism of bone resorption and lysis that occur in a diverse set of bone metastatic lesions, as well as in primary bone lesions. Compared with control bone tissue and bone biopsies from patients with nonmetastatic p...
BACKGROUND/AIM The canonical Wingless-type (WNT) pathway is involved in normal hematopoietic cell development and deregulated WNT signaling is implicated in the development of hematological malignancies. Dickkopf 1 (DKK1) acts as a modulator of the β-catenin regulated canonical pathway. Activation of DKK1 leads to apoptosis and growth suppression, whereas silencing by promoter hypermethylation ...
Tilman D Rachner ([email protected]) Stefanie Thiele ([email protected]) Andy Göbel ([email protected]) Andrew Browne ([email protected]) Susanne Füssel ([email protected]) Kati Erdmann ([email protected]) Manfred P Wirth ([email protected]) Michael Fröhner (mic...
How stem cells maintain their identity and potency as tissues change during growth is not well understood. In mammalian hair, it is unclear how hair follicle stem cells can enter an extended period of quiescence during the resting phase but retain stem cell potential and be subsequently activated for growth. Here, we use lineage tracing and gene expression mapping to show that the Wnt target ge...
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