The incidence and prevalence of diabetes mellitus are both increasing rapidly in societies around the globe. The majority of patients with diabetes succumb ultimately to heart disease, much of which stems from atherosclerotic disease and hypertension. However, the diabetic milieu is itself intrinsically noxious to the heart, and cardiomyopathy can develop independent of elevated blood pressure ...

Continuous Glucose Monitors (CGMs) provide tremendous value for diabetes detection and management. However, their high cost regulatory complications have prevented the widespread use of CGMs. On other hand, Heart Rate (HR) monitors are in wide growing popularity. In this work, we investigate connection between HR monitor CGM devices to find a cheaper alternative measuring glucose dysregulation....

Baseler WA, Dabkowski ER, Williamson CL, Croston TL, Thapa D, Powell MJ, Razunguzwa TT, Hollander JM. Proteomic alterations of distinct mitochondrial subpopulations in the type 1 diabetic heart: contribution of protein import dysfunction. Am J Physiol Regul Integr Comp Physiol 300: R186–R200, 2011. First published November 3, 2010; doi:10.1152/ajpregu.00423.2010.—Diabetic cardiomyopathy is asso...

Diabetic heart, which includes any condition causing pathological changes in blood vessels, cardiac muscle or valves and cardiac rhythm in diabetic patients, such as diabetic cardiomyopathy and ischemic heart disease, is an important cause of mortality in diabetic patients. However, strategies for the treatment of diabetic heart have not been well documented. Recent, large, clinical trials, the...

Simvastatin is a lipid-lowering agent used to treat hypercholesterolemia and to reduce the risk of heart disease. This study scrutinized the beneficial effects of simvastatin on experimental diabetic cardiomyopathy (DCM), pointing to the role of hyperglycemia-induced oxidative stress and inflammation. Diabetes was induced by intraperitoneal injection of streptozotocin and both control and diabe...

Diabetic cardiomyopathy is 1 of the major causes of death in diabetic patients, but the pathogenesis is unclear. There is evidence that RhoA, a small GTPase, might be involved in cardiac function. This study, therefore, analyzed RhoA expression and activation in hearts of diabetic rats. Male Sprague-Dawley rats were divided into control and diabetic groups of 18 each. Diabetes was induced by in...

Independent of the severity of coronary artery disease, diabetic patients have an increased risk of developing heart failure. This clinical entity has been considered to be a distinct disease process referred to as 'diabetic cardiomyopathy'. Experimental studies suggest that extensive metabolic perturbations may underlie both functional and structural alterations of the diabetic myocardium. Tra...

BACKGROUND Hyperglycemia-induced oxidative stress is one mechanism believed to underlie diabetic vascular disease. We tested the hypothesis that diabetic subjects heterozygous for extracellular superoxide dismutase (SOD3) R213G, which entails lower antioxidant capacity in tissues, have increased risk of cardiovascular disease and heart failure. METHODS We used the prospective Copenhagen Gener...