679 W E ARE PRESENTING the case histories of two children with diabetes insipidus, of particular interest because of the diversity of manifestations, the variance in etiology and the complexity of management. One patient was observed for a period of 3 years, with onset of disease at age 10 years; another was observed for a period of 8 years, with the onset of tile primary disease at 2 years and...

Diabetes insipidus is a condition in which patients produce large quantities of dilute urine. Central or neurogenic diabetes insipidus results from the failure of the posterior pituitary to make or secrete vasopressin (also called antidiuretic hormone [ADH]). Nephrogenic diabetes insipidus (NDI), which can be congenital or acquired, results from failure of the kidney to respond to vasopressin. ...

pituitary gland metastasis was seen in elderly patients, and the incidence of pituitary metastasis is 1% to 4% of all cancer patients. renal cell carcinoma is a primary malignancy in only 2.6% of pituitary metastases. we reported a 50-year-old man with pituitary metastasis from renal cell carcinoma that had signs of diabetes insipidus. he had multiple lesions in both lungs, and bone scan involv...