The influence of a Mg-deficient diet on blood pressure and various hormonal systems was examined in Wistar rats (WR) and spontaneously hypertensive rats (SHR). The WR and SHR were individually divided into 2 groups. The Mg-deficient diet was given to one group, and a Mg-containing diet was given to the other group for 3 weeks. During this experimental period, the body weight, blood pressure, ur...

Klotho is a membrane protein participating in the inhibitory effect of FGF23 on the formation of 1,25-dihydroxyvitamin-D(3) [1,25(OH)(2)D(3)]. It participates in the regulation of renal tubular phosphate reabsorption and stimulates renal tubular Ca(2+) reabsorption. Klotho hypomorphic mice (klotho(hm)) suffer from severe growth deficit, rapid aging, and early death, events largely reversed by a...

Two 42-d experiments were conducted with 60 and 100 Large White growing pigs, initially weighing 17.7 and 18.3 kg, respectively, to determine their ability to select between diets varying in lysine content. Dietary lysine levels ranged from .60 to 1.40%. A common basal diet (17% crude protein, 3.3 Mcal digestible energy/kg) based on corn, soybean meal and peanut meal was used in both experiment...

The antioxidative effect of conjugated linoleic acid (CLA) was examined by determining lipid peroxidation and antioxidative enzyme activities. Male Sprague-Dawley rats were fed one of the experimental diets-normal diet, vitamin E-deficient control diet, 0.5% CLA vitamin E-deficient diet, or 1.5% CLA vitamin E-deficient diet for 5 wk. Hepatic thiobarbituric acid reactive substances (TBARS) were ...

Of nineteen rats on a complete diet (Group III, Diet + C. L. O.), none showed foci of squamous keratinizing epithelium in abnormal situations. Of twenty-six rats on a diet deficient in vitamins A and D (Group I, Diet-A-D), twenty-three showed metaplastic changes of varying degree in one or more organs; the metaplasia was of columnar, cuboidal, and transitional epithelium to the squamous keratin...

The lipid compositions of whole brain homogenates and microsomal and myelin fractions isolated from the brains of 6-month-old rats raised on a lab chow diet, a fatty acid-deficient diet, and a deficient diet supplemented with 5% (w/w) corn oil were determined. Brain and body weights were significantly lower in the fatty acid-deficient group. The compositions of alk-1-enyl groups and phospholipi...

Weanling male Wistar rats fed a choline-deficient diet develop acute kidney injury. Menhaden oil, which is a very important source of omega-3 fatty acids, has a notorious protective effect. The mechanism of this protection is unknown; one possibility could be that menhaden oil changes renal lipid profile, with an impact on the functions of biological membranes. The aim of this work was to study...

1. Indol, orally administered, causes anemia when certain deficient diets are fed. 2. The same amount of indol causes no considerable hematologic disturbance when normal diets are fed. 3. The anemia can be cured by supplementing the diet with liver extract, or by substituting a normal diet for the deficient diet. 4. Neither the diet alone nor the administration of indol alone produces marked an...

Increased synthesis of ornithine aminotransferase [EC 2.6.1.13] (OAT) in the kidney of pyridoxine-deficient rats has been reported previously (Ikeda, M. and Okada, M. (1985): J. Nutr. Sci. Vitaminol., 31, 553-561). In this report the effects of 3,3',5'-triiodothyronine (T3) and estradiol on OAT activity in the kidney of rats given pyridoxine-deficient and control diets were studied. T3 induced ...

A diet deficient in n-3 fatty acids dramatically reduces docosahexaenoic acid (4.8-fold) and 20:5n-3 content in murine total peroxisomal phospholipids, and conversely increases 22:5n-6 (17.1-fold) and also, to a lesser extent, 20:4n-6. This was also found in purified phosphatidylethanolamine and phosphatidylcholine. After changing the non-deficient diet (containing alpha-linolenic acid, ALA) to...