نتایج جستجو برای: cyanopindolol
تعداد نتایج: 45 فیلتر نتایج به سال:
Serotonergic modulation of precerebellar nuclei may be crucial for the function of the entire cerebellar system. To study the effects of serotonin (5-HT) on neurons located within the pontine nuclei (PN), the main source of cerebellar mossy fibers, we performed standard intracellular recordings from PN neurons in a slice preparation of the rat pontine brain stem. Application of 5 microM 5-HT si...
Although ligand-free, constitutive b2-adrenergic receptor (AR) signaling has been demonstrated in naive cell lines and in transgenic mice overexpressing cardiac b2-AR, it is unclear whether the dominant cardiac b-AR subtype, b1-AR, shares the ability of spontaneous activation. In the present study, we expressed human b1or b2-AR via recombinant adenoviral infection in ventricular myocytes isolat...
In the current study, we investigated the mechanism by which protein kinase C (PKC) regulates the expression of b1-adrenergic receptor (b1AR) mRNA in rat C6 glioma cells. Exposure of the cells to 4b-phorbol-12-myristate-13-acetate (PMA), an activator PKC, resulted in a down-regulation of both b1AR binding sites and mRNA levels in a timeand concentration-dependent manner. This effect was not obs...
The Madin-Darby canine kidney (MDCK) cell line, derived from distal tubule/ collecting duct, expresses differentiated properties of renal tubule epithelium in culture. We studied the expression of adrenergic receptors in MDCK to examine the role of catecholamines in the regulation of renal function. Radioligand-binding studies demonstrated, on the basis of receptor affinities of subtype-selecti...
The understanding of the function of 1-adrenergic receptors in the brain has been limited due to a lack of specific ligands and antibodies. We circumvented this problem by using transgenic mice engineered to overexpress either wild-type receptor tagged with enhanced green fluorescent protein or constitutively active mutant 1-adrenergic receptor subtypes in tissues in which they are normally exp...
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