نتایج جستجو برای: ctgf

تعداد نتایج: 1816  

Journal: :American journal of physiology. Renal physiology 2006
Peggy Roestenberg Frans A van Nieuwenhoven Jaap A Joles Claudia Trischberger Paula P Martens Noelynn Oliver Jan Aten Jo W Höppener Roel Goldschmeding

Connective tissue growth factor (CTGF) is overexpressed in diabetic nephropathy (DN) and has therefore been implicated in its pathogenesis. The objective of the present study was to determine the tissue distribution of increased CTGF expression and the relationship of plasma, urinary, and renal CTGF levels to the development and severity of DN. We studied the relationship between CTGF and renal...

2018
Kunihiro Hayakawa Keigo Ikeda Maki Fujishiro Yuko Yoshida Takuya Hirai Hiroshi Tsushima Tomoko Miyashita Shinji Morimoto Yasushi Suga Kenji Takamori Hideoki Ogawa Iwao Sekigawa

Background Connective tissue growth factor (CTGF) is a multifunctional cellular protein and playing a role as a central mediator in tissue remodeling and fibrosis. The physiological function of CTGF in psoriasis is unknown. Objective The purpose of this study was to investigate the function of CTGF in psoriasis using the established imiquimod (IMQ)-induced psoriasis murine model and psoriasis...

2009
Young Ki Lee Eun-Ji Kim Jung Eun Lee Jung Woo Noh Yoon-Goo Kim

Connective tissue growth factor (CTGF) is known to be a profibrotic growth factor, which mediate the fibrotic effect of transforming growth factor-beta (TGF-beta) and to stimulate cell proliferation and matrix production. CTGF has been shown to be hypoxia-inducible in several cell types. Here we investigated the effect of hypoxia on CTGF gene expression in cultured mouse renal tubular cells (MT...

Journal: :Hypertension 2007
Norimichi Koitabashi Masashi Arai Shinya Kogure Kazuo Niwano Atai Watanabe Yasuhiro Aoki Toshitaka Maeno Takashi Nishida Satoshi Kubota Masaharu Takigawa Masahiko Kurabayashi

Excessive fibrosis contributes to an increase in left ventricular stiffness. The goal of the present study was to investigate the role of connective tissue growth factor (CCN2/CTGF), a profibrotic cytokine of the CCN (Cyr61, CTGF, and Nov) family, and its functional interactions with brain natriuretic peptide (BNP), an antifibrotic peptide, in the development of myocardial fibrosis and diastoli...

Journal: :Investigative ophthalmology & visual science 2001
P A Folger D Zekaria G Grotendorst S K Masur

PURPOSE Transforming growth factor beta1 (TGF-beta) stimulates the differentiation of myofibroblasts as indicated by the nascent expression of alpha-smooth muscle (alpha-SM) actin protein and its organization into stress fibers. Downstream messengers of TGF-beta in the conversion from the fibroblast to the myofibroblast phenotype were investigated. Whether TGF-beta increases the transcription o...

1999
DENNIS A. RICUPERO DAVID C. RISHIKOF PING-PING KUANG CHRISTINE F. POLIKS RONALD H. GOLDSTEIN

Ricupero, Dennis A., David C. Rishikof, Ping-Ping Kuang, Christine F. Poliks, and Ronald H. Goldstein. Regulation of connective tissue growth factor expression by prostaglandin E2. Am. J. Physiol. 277 (Lung Cell. Mol. Physiol. 21): L1165–L1171, 1999.—Transforming growth factor-b (TGF-b) stimulates a1(I) collagen mRNA synthesis in human lung fibroblasts through a mechanism that is partially sens...

2015
Sabrina Kuespert Benjamin Junglas Barbara M Braunger Ernst R Tamm Rudolf Fuchshofer

Connective tissue growth factor (CTGF) induces extracellular matrix (ECM) synthesis and contractility in human trabecular meshwork (HTM) cells. Both processes are involved in the pathogenesis of primary open-angle glaucoma. To date, little is known about regulation and function of CTGF expression in the trabecular meshwork (TM). Therefore, we analysed the effects of different aqueous humour pro...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009
Sven Kroening Svetlana Solomovitch Martin Sachs Bernd Wullich Margarete Goppelt-Struebe

BACKGROUND Hepatocyte growth factor (HGF) is a pleiotropic protein with renoprotective functions, which have been attributed at least in part to its ability to counteract the profibrotic effects of transforming growth factor beta (TGF-beta). A major downstream mediator of TGF-beta is connective tissue growth factor (CTGF). However, the molecular mechanisms of CTGF regulation by HGF have not yet...

Journal: :Circulation research 2005
Juan Rodriguez-Vita Marta Ruiz-Ortega Mónica Rupérez Vanessa Esteban Elsa Sanchez-López Juan José Plaza Jesús Egido

Endothelin (ET)-1 is a potent vasoconstrictor that participates in cardiovascular diseases. Connective tissue growth factor (CTGF) is a novel fibrotic mediator that is overexpressed in human atherosclerotic lesions, myocardial infarction, and experimental models of hypertension. In vascular smooth muscle cells (VSMCs), CTGF regulates cell proliferation/apoptosis, migration, and extracellular ma...

Journal: :Investigative ophthalmology & visual science 2010
Edward G Tall Audrey M Bernstein Noelynn Oliver Julia L Gray Sandra K Masur

PURPOSE Connective tissue growth factor (CTGF) is induced by transforming growth factor-beta (TGF-β) after corneal wounding. This study addressed the role of the extracellular matrix in the induction of CTGF by TGF-β. METHODS Human corneal fibroblasts (HCFs) were grown on fibronectin (FN), vitronectin (VN), or collagen (CL) in supplemented serum-free media alone or with TGF-β1 or fibroblast g...

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