Context Basal and poststimulation salivary cortisol and cortisone levels can be useful in the diagnosis of adrenal insufficiency. However, little is known about the optimal cutoffs and performance characteristics of these tests. Objective To derive the cutoff values and study the performance characteristics of salivary cortisol and salivary cortisone in the diagnosis of adrenal insufficiency....

In man, cortisone has not been shown to have any appreciable effect on long-standing fibrosis. Kennedy, Pare, Pump, Beck, Johnson, Epstein, Venning, and Browne (1951) treated a case of pulmonary silicosis with some clinical improvement in the patient's condition, although this was not supported by the x-ray findings; and Kennedy (1954) has recently reported rather similar findings (subjective b...

CONTEXT Corticosteroid is a well-established cause of drug-induced pancreatitis. However, acute pancreatitis from intra-articular injection of corticosteroid has never been described. CASE REPORT A 69-year-old male presented with acute abdominal pain and was diagnosed with acute pancreatitis. The patient had one episode of acute pancreatitis two year earlier. Both episodes occurred after intr...

Several rat tissues decarboxylate Cl4 L-histidine and bind the resulting histamine in stable form. The pyloric portion of the stomach is by far the most active. Pretreatment of the rats with cortisone appears to reduce the histamine-binding activity of most tissues while prior adrenalectomy increases it. The stomach is the exception; here the reverse is true. Using rat lung as a test tissue, it...

OBJECTIVES To assess the cost-effectiveness of providing practical training to general practitioners (GPs) in shoulder problems, and administering a local anaesthetic (lignocaine) vs steroidal (cortisone) injection. METHODS A cost-effectiveness analysis conducted alongside a cluster randomized trial with a factorial design, in general practices across five centres within the UK. A total of 15...

The responses of the adaptive enzymes, serine dehydrase (L-serine hydro-lyase (deaminating), EC 4.2.1.13), ornithine transaminase (L-ornithine:2-oxoacid aminotransferase, EC 2.6.1.13), glucose 6-phosphate dehydrogenase (D-ghCOSe 6-phosphate:NADP oxidoreductase, EC 1.1.1.49), and glucokinase (ATP:o-glucose 6-phosphotransferase, EC 2.7.1.2), in rat liver were studied in relation to changes in the...

Cortisone, whether used prophylactically or therapeutically, did not appear to have any beneficial effect in reducing the size of the mvocardial infarcts produced by coronary artery ligation in dogs. No significant differences were noted between the control and cortisone-treated animals in respect to the vascularity of the infarcted area or the rate of healing.stein reported recently that corti...

There have been several reports indicating that cortisone suppresses or “blocks” the tuberculin skin reaction in man and experimental animals.1-3 Also it has been shown that ACTH or cortisone inhibits the development of the Arthus phenomenon due to a suppression of antibody formation.4 Recently it has been demonstrated that ACTH or cortisone did not prevent histamine effects on sensitized guine...