To characterize the electrophysiologic properties of the ventricular arrhythmias occurring during reperfusion after acute coronary artery ligation, a study was undertaken to correlate the time course of appearance of such arrhythmias with specific electrophysiologic mechanisms. Thirty-seven dogs survived 30minute ligations of the left descending coronary artery, and all had either instantaneous...

RECENT reports have indicated that anomalous coronary arteries originating from the pulmonary artery may act as a channel for left-to-right shunt.1-4 Thus a large portion of the coronary blood flow may bypass the coronary capillary bed, pass through arterial anastomoses, and enter directly into the pulmonary artery by retrograde flow through the anomalous coronary with resultant myocardial isch...

We investigated in Lewis normotensive rats the effect of coronary artery ligation on the expression of cardiac angiotensin-converting enzymes (ACE and ACE 2) and angiotensin II type-1 receptors (AT1a-R) 28 days after myocardial infarction. Losartan, olmesartan, or the vehicle (isotonic saline) was administered via osmotic minipumps for 28 days after coronary artery ligation or sham operation. C...

The present study focused on the role of sympathetic renal nerve activity, in mediating congestive heart failure-induced sodium retention following experimental chronic myocardial infarction. Groups of male Wistar rats (240-260 g) were studied: sham-operated coronary ligation (CON3W, N = 11), coronary ligation and sham-operated renal denervation (INF3W, N = 19), 3 weeks of coronary ligation and...

Aroutine transthoracic echocardiogram (TTE) was performed in a 72-year-old woman with signs and symptoms of heart failure. The 2D TTE images revealed an enlarged right coronary artery (RCA) with reverse flow draining into the pulmonary trunk and the presence of dilated septal vessels (Figure 1). Coronary angiography and MRI confirmed the previous echocardiographic findings (Figures 2 to 4). Acc...

The response of pulmonary blood volume (PBV) and extravascular lung water (EVLW) was examined by indicator-dilution techniques in 14 "open chest" dogs, seven that underwent coronary occlusion (group 2) and seven that served as controls (group 1). Data were obtained in a control stage (control stage 1) 45 min after coronary ligation (control stage 2), and 90 min after the left atrial pressure ha...

Heart failure evokes diaphragm weakness, but the mechanism(s) by which this occurs are not known. We postulated that heart failure increases diaphragm free radical generation and that free radicals trigger diaphragm dysfunction in this condition. The purpose of the present study was to test this hypothesis. Experiments were performed using halothane-anesthetized sham-operated control rats and r...

OBJECTIVES The present study investigated the effects of tumor necrosis factor (TNF)-alpha and angiotensin II (ANG II) on cardiac remodeling and dysfunction at the early stage of acute myocardial infarction (MI) by using a novel heterotopic cardiac transplantation-coronary ligation model. BACKGROUND A recent clinical study has demonstrated a possible role of monocytosis in the development of ...

Objective(s): Electrical inhomogeneity between ischemic and non ischemic myocardium is the basis of arrhythmia which occurs following coronary artery occlusion. The leakage of potassium from the ischemic region to the non ischemic region is very effective in the generation of these arrhythmias. The aim of this study is to research the effect of ATP-dependent potassium (KATP) channel blocker (gl...