Binding sites analogous to those of sp(3) carbon are presented by concanavalin A. This lectin has now been cross-linked with a bismannopyranoside which contains the C(2) spacer required to form the computer-modeled diamondlike three-dimensional protein lattice shown in the picture.

Density-inhibited 3T3 mouse fibroblasts were treated for 10 min with nine concentrations of Pronase ranging from 0.25 to 40 mug/ml. Concanavalin A-specific agglutinability increased from control values of about 25% to plateau values of about 80%. None of these Pronase concentrations brought about an increase in cell number within 84 hr. Pronase-treated cells remained responsive to growth stimul...

Inhibition studies on the concanavalin A-dextran interaction have been extended using as inhibitors the members of the maltose-, isomaltose-, and methyl cy-isomaltoside series, amino and N-acetyl amino sugars, and a number of oligosaccharides containing more than one linkage type. The interaction of the plant protein at the terminal chain ends of the a-linked glucans and mannans has been essent...

Normal human plasma lipoprotein system consists of four distinct lipoprotein families referred to as LP-A,* LP-B, LP-C, and LP-D [l-4]. In the density above 1.019 g/ml, the lipoprotein families occur mainly as separate physicochemical entities [3, 51. However, in the density below 1.019 gJrn1 the lipoprotein families B and C and, if present, lipoprotein families A and D form an association comp...

An algebra A is uniform if for each θ ∈ ConA, every two classes of θ have the same cardinality. It was shown by W. Taylor that coherent varieties need not be uniform (and vice versa). We show that every coherent variety having transferable congruences is uniform.

Adsorption of bioparticles to affinity surfaces involves polyvalent interactions, complicating greatly the recovery of the adsorbed material. A unique system for the efficient binding and release of different cells and particles is described. Affinity-bound bioparticles and synthetic particles are detached from the macroporous hydrogel matrix, a so-called cryogel, when the cryogel undergoes ela...

Let A = (A;F ) be an algebra and ConA its congruence lattice. Recall that A is congruence uniform (see e.g. [1], [5]) if for each Θ ∈ ConA and every a, b ∈ A, card[a]Θ = card[b]Θ. Examples of congruence uniform algebras are e.g. groups, rings or Boolean algebras. A variety V is congruence uniform if each A ∈ V has this property. It was proved by W. Taylor [5] that every congruence uniform varie...

Immunization with MFS-180 vaccine prepared in the presence of glutaraldehyde (0.05%), lipopolysaccharide (LPS) (100 micrograms/ml), and concanavalin A (Con A) (200 micrograms/ml) could protect Swiss mice against a subsequent challenge by 1 X 10(6) MFS-180 cells. The sequence of attachment of LPS and Con A to glutaraldehyde-treated cells as found to determine the efficacy of the vaccine. LPS cou...

Results of experiments have indicated that reduction in biological activities at high concentrations of Japanese encephalitis virus is caused by aggregates of the virus by concanavalin A. The possibility exists that the concanavalin A binding site is different from hemagglutination and antireceptor sites of Japanese encephalitis virus.