Primary CNS lymphoma is an aggressive form of non-Hodgkin lymphoma whose growth is restricted to the central nervous system. We used cDNA microarray analysis to compare the gene expression signature of primary CNS lymphomas with nodal large B-cell lymphomas. Here, we show that while individual cases of primary CNS lymphomas may be classified as germinal center B-cell, activated B-cell, or type ...

Abstract The blood-brain barrier (BBB) has a significant contribution to the protection of central nervous system (CNS). However, it also limits brain drug delivery and thereby complicates treatment CNS diseases. development safe methods for an effective medications nanocarriers can be revolutionary step in overcoming this limitation. Here, we report unique properties lymphatic deliver tracers ...

Cystic nephromas (CNs) are uncommon, benign renal neoplasms reported in infants/young children of both genders and adult females, concerning the pediatric population few studies have been conducted. The diagnosis cystic nephroma is based on clinical signs, imaging tests, anatomo-pathological study. In children, CNs can appear as a palpable abdominal mass most cases, hematuria or recurrent urina...

OBJECTIVE Liver transplantation from deceased donors with a central nervous system (CNS) malignancy has some risk of tumor transmission to the recipient. Though the risk is small, this group of donors is regarded as marginal. The use of marginal grafts may be an acceptable alternative practice in order to expand the donor pool in countries where there is a shortage of donated organs. The aim of...

Abstract Although immune checkpoint inhibitors (ICI) have become a useful tool in the management of central nervous system (CNS) metastases, only subset patients experience durable clinical responses and prognosis continues to remain poor. In particular, role ICI for CNS metastases from breast cancer has also not been adequately explored. CDK4/6 inhibition shown sensitize extracranial tumors IC...

Central nervous system tumors take advantage of the unique immunology of the CNS and develop exquisitely complex stromal networks that promote growth despite the presence of antigen-presenting cells and tumor-infiltrating lymphocytes. It is precisely this immunological paradox that is essential to the survival of the tumor. We review the evidence for functional CNS immune privilege and the impa...

Abstract Atypical teratoid/rhabdoid tumors (AT/RTs) of the central nervous system (CNS) are rare, aggressive, early childhood with unfavorable prognosis. There have been 31 cases reported children AT/RT CNS and extra primary tumors. In addition to its aggressive tendencies, malignant rhabdoid (MRTs) kidney also shown a common genetic abnormality-inactivating mutation SMARC B1/INI-gene. We repor...

OBJECTIVE To determine the frequency of central nervous system (CNS) tumors in the first fifty years of the National Institute of Neurology and Neurosurgery of Mexico Manuel Velasco Suárez (Instituto Nacional de Neurología y Neurocirugía de México, INNN) from 1965 to 2014. MATERIALS AND METHODS A total of 16 116 institutional records of CNS tumors were analyzed. The frequency and distribution...

UNLABELLED The etiology of central nervous system (CNS) tumor heterogeneity is unclear. To clarify this issue, a novel animal model was developed of glioma and atypical teratoid/rhabdoid-like tumor (ATRT) produced in rats by nonviral cellular transgenesis initiated in utero. This model system affords the opportunity for directed oncogene expression, clonal labeling, and addition of tumor-modify...