PURPOSE The unmanageable side effects caused by current chemotherapy regimens to treat cancer are an unresolved problem. Although many phytonutrients are useful as chemoprevention without side effects, their effects are slower and smaller than conventional chemotherapy. In the present work, we examined the cumulative effect of two phytonutrients, curcumin and citral, on breast cancer cell lines...

Alpha-interferon (alpha-IFN) and gamma-interferon (gamma-IFN) are highly effective biologic agents in the treatment of chronic myelogenous leukemia (CML). 4-hydroperoxycyclophosphamide (4-HC) is the most commonly used chemotherapeutic drug when purging bone marrow contaminated with malignant cells. To investigate the efficacy of alpha-IFN, gamma-IFN and 4-HC as purging agents in CML patients, K...

Previous studies have demonstrated the in vitro and in vivo activity of CC-5013 (Revlimid), an immunomodulatory analog (IMiD) of thalidomide, in multiple myeloma (MM). In the present study, we have examined the anti-MM activity of rapamycin (Rapamune), a specific mTOR inhibitor, combined with CC-5013. Based on the Chou-Talalay method, combination indices of less than 1 were obtained for all dos...

The Chou-Fasman method has been a widely used method for protein secondary structure prediction. This method is based on knowledge about amino acid residues potential to form αhelical regions or β-sheet regions in proteins. Our main interest in this study was to examine the reliability of these Chou-Fasman parameters. We have calculated the Chou-Fasman parameters, with 95% confidence limits, ou...

Objective(s): This paper aims to investigate synergistic inhibition of polysaccharide from Sepia esculenta ink (SIP), a newly isolated marine polysaccharide in our laboratory, on breast cancer MDA-MB-231 cells exposed to cisplatin. Materials and Methods: Cell viability of MDA-MB-231 cells was determined by CCK 8 assay. Median-effect concentration was analyzed using Chou-Talalay method that was ...

Background: Breast and esophageal cancer are the most aggressive prominent causes of death worldwide. In addition, these cancers showed resistance to current chemotherapy regimens with limited success rates fatal outcomes. Recently many studies reported significant cytotoxic effects phenolic terpene fractions extracted from various Prunus spe...

Chou, P. Y., Adler, A. J. & Fasman, G. D. (1975) J. Mol. Biol. 96,2945 Coy, D. H., Kastin, A. J., Schally, A. V., Morin, O., Caron, N. G., Labrie, F., Walker, J. M., Fertel, R., Berntson, G. G. & Sandman, C. A. (1977) Biochem. Biophys. Res. Commun. 73, 632-638 ... Crawford, J. L., Lipscomb, W. N. & Schellman, C. G. (1973) Proc. Natl. Acad. Sci. U.S.A. 70, 538-542 F a s m , G. D., Chou, P. Y. & ...

Chou et al. (Applied Soft Computing 12 (2012) 64-71) used combination of fuzzy AHP (Analytic Hierarchy Process) and fuzzy DEMATEL (Decision Making Trial and Evaluation Laboratory) in human resource for science and technology (HRST). For applying the fuzzy DEMATEL method there is a need to find the multiplicative inverse of a fuzzy matrix. In this paper, it is pointed out that the method, used b...