نتایج جستجو برای: chlorambucil
تعداد نتایج: 2068 فیلتر نتایج به سال:
Chemotherapy combinations with monoclonal antibodies are now the basis for treatment of chronic lymphocytic leukemia. Rituximab, the most widely used anti-CD20 antibody in routine clinical practice, led not only to improvement of progression-free survival, but also to improvement of overall survival in previously untreated patients with good performance status in combination with fludarabine an...
We reviewed the charts of 20 patients with sympathetic ophthalmia who were seen in the uveitis clinic at the Eye and Ear Infirmary within an 11-year period. Of these 20 patients 14 maintained 20/50 or better visual acuity in at least one eye. We found early enucleation to be associated with a better visual prognosis, possibly due to earlier diagnosis and faster, more aggressive therapy rather t...
Prolymphocytic leukemia is characterized by marked splenomegaly, distinctive cellular morphologic characteristics, and a poor clinical course. Five patients with typical PL were treated systematically with vincristine/prednisone, chlorambucil/prednisone, splenic irradiation, splenectomy, and other chemotherapy regimens. No patient responded to vincristine/prednisone. Two patients responded to c...
Ethacrynic acid and piriprost (6,9-deepoxy-6,9-(phenylimino)-A''8prostaglandin I,) have been shown to potentiate the cytotoxic activity of chlorambucil in rat and human tumor cell lines. Walker 256 rat breast carcinoma cells (WS), with acquired resistance to nitrogen mustards (WR), and two human colon carcinoma cell lines, HT 29 and BE, were sensitized to chlorambucil when either ethacrynic aci...
The cytological alterations in primary short-term tissue cultures of 196 malignant neoplasms, eight benign neoplasms, and fourteen normal tissues of human origin following a 96-hour exposure to several chemotherapeutic agents individually have been described and evaluated. Each replicate culture from a biopsy specimen responded in vitro as an individual entity. Cell populations were either sens...
PURPOSE To report the outcome of oral chlorambucil as a single treatment in patients with orbital mucosa-associated lymphoid tissue (MALT) lymphoma. DESIGN Retrospective nonrandomized clinical study. PARTICIPANTS Thirty-three patients with isolated orbital MALT lymphoma. METHODS Medical records of all patients with histology-verified orbital MALT lymphoma treated with oral chlorambucil at...
On November 1, 2013, the U.S. Food and Drug Administration (FDA) approved obinutuzumab (GAZYVA; Genentech, Inc.), a CD20-directed cytolytic antibody, for use in combination with chlorambucil for the treatment of patients with previously untreated chronic lymphocytic leukemia (CLL). In stage 1 of the trial supporting approval, patients with previously untreated CD20-positive CLL were randomly al...
Cultured cells with elevated levels of cytoplasmic metalloidionein (MT), a small-molecular-weight protein extremely rich in cysteine. showed resistance against the alkylating drug chlorambucil. One human epithelial line (HE) and one mouse fibroblast line (CI 1D) were used, as well as substrains of both cell lines (HE10oand CI 1D10o).The substrains contain large amounts of MT. Dose-survival curv...
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