Members of the six-transmembrane segment family of ion channels share a common structural design. However, there are sequence differences between the members that confer distinct biophysical properties on individual channels. Currently, we do not have 3D structures for all members of the family to help explain the molecular basis for the differences in their biophysical properties and pharmacol...

Fast synaptic neurotransmission is mediated by transmitter-activated conformational changes in ligand-gated ion channel receptors, culminating in opening of the integral ion channel pore. Human hereditary hyperekplexia, or startle disease, is caused by mutations in both the intracellular or extracellular loops flanking the pore-lining M2 domain of the glycine receptor alpha1 subunit. These flan...

multicast routing is one of the most important services in multi radio multi channel (mrmc) wireless mesh networks (wmn). multicast routing performance in wmns could be improved by choosing the best routes and the routes that have minimum interference to reach multicast receivers. in this paper we want to address the multicast routing problem for a given channel assignment in wmns. the channels...

many appealing multicast services such as on-demand tv, teleconference, online games and etc. can benefit from high available bandwidth in multi-radio multi-channel wireless mesh networks. when multiple simultaneous transmissions use a similar channel to transmit data packets, network performance degrades to a large extant. designing a good multicast tree to route data packets could enhance the...

Abstract Cold-formed steel structures have been widely applied in structural buildings with advantages manufacturing, transportation and assembly. Holes can be pre-punched the sectional members to allow technical pipes go throughout such as electricity, water or ventilation. This affects capacities of these which considered design standards America Australia/New Zealand. The paper, therefore, i...

This paper studies the supply chain system composed of online brand owners based on pure network sales to offline expansion, takes single channel model, establishes two dual-channel structure models direct selling model and distribution compares analyzes influence different structures pricing, demand optimal profit members. Research shows that brands in development strategy choice open stores f...