Introduction: Infections from gram negative bacilli is a challenge for clinicians and laboratory personnel. Treatment of these infections remained as an area concern. Both fluroquinolones cephalosporins are most common choice antibiotics. Despite Cephalosporins, being drug they expensive also showed many adverse reactions. This study, compares reevaluates the susceptibility bacteria to (ciprofl...

Outer membrane permeation of Bacteroides fragilis by cephalosporins was examined by a previously described method. The permeation parameters of cephalosporins in B. fragilis were close to 10(-5) cm3/min per microgram of cell dry weight. These values were about an order of magnitude lower than those in Escherichia coli. In B. fragilis, the permeation was not directly proportional to the hydrophi...

aim : this study aims to determine the serogroup distribution and molecular diagnosis, as well as antimicrobial resistance profiles among shigella spp. isolated from patients with diarrhea in kerman, southeast of iran.   background : shigella species are frequent cause of bacterial dysentery worldwide. previous studies have been reported that s. sonnei and s. flexneri are the most prevalent ser...

Eight heterogeneous vancomycin-intermediate S. aureus (h-VISA) and seven VISA clinical isolates confirmed by the population analysis profile/area under the curve ratio (PAP/AUC) were collected. We further performed the PAP/AUC, time-killing methods and MIC tests using vancomycin/teicoplanin alone or combination with susceptible breakpoint concentrations of cefazolin, cefmetazole, cefotaxime, an...

Acetaminophen and indomethacin either did not alter or partially reversed the inhibition of lymphocyte mitogenic responses by cephalosporins. Aspirin at concentrations of >/=100 mug/ml in cultures containing cephalosporins reduced the response below the level with either drug alone.

Thirty-one Cephalosporin compounds were modeled using the multivariate image analysis and applied to the quantitative structure activity relationship (MIA-QSAR) approach. The acid dissociation constants (pKa) of cephalosporins play a fundamental role in the mechanism of activity of cephalosporins. The antimicrobial activity of cephalosporins was related to their first pKa by different models. B...

Background: Plasmid mediated quinolone resistance (PMQR) has been shown to play an important role in resistance not only to quinolones, but also β-lactams and aminoglycosides. In fact, qnr genes are frequently carried along with β-lactamase determinants on the same plasmids. We studied the prevalence of qnrA, qnrB, qnrS and aac(6’)-Ib-cr genes among quinolone and cephalosporin resistant clinica...

The clinical picture (fever, cough, sputum, auscultatory changes), peripheral blood parameters (leukocytosis, ESR) and radiological data are currently the criteria for suspecting bacterial pneumonia in patients with SARS CoV-2 infection indication of antibacterial treatment. initiation antibiotic therapy is empirical by taking into account pathogens most likely involved community-acquired (Str ...

Cephalosporins are one of the most commonly prescribed classes of antibiotics. Immediate IgE-mediated hypersensitivity reactions have been reported with use of a specific cephalosporin, as a cross-reaction between different cephalosporins or as a cross-reaction to other β-lactam antibiotics, namely, penicillin. Historically, frequent reports of anaphylaxis following administration of first- and...