Analysis of cell-free DNA (cfDNA) in the blood has shown promise for monitoring a variety biological processes. Plasma cfDNA is mixture comprising molecules released from various bodily tissues, mediated by characteristic fragmentations occurring during cell death. Fragmentation non-random and contains tissue-of-origin information, which been demonstrated circulating fetal, tumoral, transplante...

Background: Alpinia galanga L. belonging to the family Zingiberaceae is widely grown in the state of Kerala, India. They are effective antioxidant and free radical scavenger under both in vitro and in vivo condition. The efficacy of the isolated flavonoids in conferring protection from radiation induced damages to genomic DNA was studied. Materials and Methods: The bioflavonoids, galangin and k...

BACKGROUND Cell-free fetal DNA and cell-free total DNA in maternal circulation have been proposed as potential markers for noninvasive monitoring of the placental condition during the pregnancy. However, the correlation of and change in cell-free fetal DNA and cell-free total DNA in spontaneous abortion (SA) with fetal chromosomal aneuploidy have not yet been reported. Therefore, we investigate...

Epigenetic changes of DNA, including methylation, have long been recognized as key indicators various diseases, aging, cancer, and neurological disorders. Biomarker discoveries based on distinct methylation patterns for both hypermethylation hypomethylation lead the way in discovery novel diagnosis treatment targets. Many different approaches are present to detect level whole genome (whole bisu...

Objective: To evaluate low-molecular-weight (LMW) DNA as possible prognostic biomarker in acute ischemic and hemorrhagic stroke. Methods:  LMW DNA samples were isolated from plasma and cerebrospinal fluid by phenol deproteinization, analyzed by gradient polyacrylamide electrophoresis and quantified by spectrophotometry. Results: Two common types of the stroke, ischemic and hemorrhagic, differ...