The shoots of Salvia officinalis growing in MS liquid medium supplemented with IAA 0.1 mg l-1) and BAP (0.45 mg l-1) were treated with methyl jasmonate (MeJA) to increase production of compounds with antioxidant activity (carnosic acid, carnosol and rosmarinic acid). The increase in metabolite production depended on MeJA concentration, the period of exposure to elicitor and type of compound. Th...

Plants extracts are increasingly used in food, cosmetic and pharmaceutical. This review presents the state of art last 20 years separation extraction nonvolatile compounds, mainly from rosmarinus leaves, especially focused on their suitability for rosmarinic acid, carnosol carnosic acid. In Lamiaceae species, bioactive compounds polyphenols, flavonoids di- or triterpenes, has been achieved by R...

We investigated the early events involved in loss of mitochondrial membrane potential (DeltaPsi(mt)) leading to apoptosis in cells derived from patients with acute lymphocytic leukemia after exposure to phenolic antioxidants. Using the nitric oxide binding dye diaminofluorescein-FM diacetate, we found that intracellular nitric oxide (NO) levels increased significantly within 4h after exposure t...

The y-aminobutyric acid (GABAA) receptor is part of a supramolecular complex which is responsible for gating a chloride channel in the brain.1} Several different classes of compounds interact with this complex, e.g. 1 ,4-benzodiazepines, barbiturates, some steroids, and f-butylbicyclophosphorothionate (TBPS). The convulsant picrotoxin2) and the diterpenes carnosol and carnosic acid3) bind to th...