In 1954 Christie and Judah (3) in a study of the mechanism of action of carbon tetrachloride advanced the view that the primary locus of action of this hepatotoxin was the membranes of the liver mitochondria. Dianzani (4-6) showed that after carbon tetrachloride or phosphorus poisoning or after a choline deficient diet, there was evidence for uncoupling of oxidative phosphorylation, loss of mit...

We have observed two high-valent arylpalladiumfluoride complexes that afford carbon-fluorine bond formation upon thermolysis.

Several studies have suggested that the carbon sink in the Southern Ocean-the ocean's strongest region for the uptake of anthropogenic CO2 -has weakened in recent decades. We demonstrated, on the basis of multidecadal analyses of surface ocean CO2 observations, that this weakening trend stopped around 2002, and by 2012, the Southern Ocean had regained its expected strength based on the growth o...

The present study determines the efficacy of N-acetyl cysteine (NAC) on marker enzymes, lipid peroxidation and antioxidants in carbon tetrachloride induced hepatotoxicity in rats. Carbon tetrachloride (CCl4) (3 mL/kg/week) administered subcutaneously to albino Wistar rats for a period of three months significantly increased the activities of marker enzymes in plasma such as aspartate transamina...

Both acute and chronic exposure to carbon monoxide (CO) gas can have serious and permanent effects on a person’s health and vision, especially if left untreated. The brain and eyes are at risk upon exposure to this clear, odorless gas due to the large oxygen demands of these structures. This teaching case report highlights the need for eyecare professionals to recognize the possible ocular, sys...

1. The general features of the reaction by which carbon tetrachloride stimulates lipid peroxidation have been elucidated in rat liver microsomal suspensions and in mixtures of microsomes plus cell sap. The production of lipid peroxides has been correlated with malonaldehyde production in the systems used. 2. The stimulation of malonaldehyde production by carbon tetrachloride requires a source o...

Liver function tests, thyroxin and triiodothyronine levels, and hepatic 5’deiodinase and glutathione peroxidase enzyme activities were measured. Triiodothyronine levels in the carbon tetrachloride group and carbon tetrachloride + selenium group were significantly lower than in the control group (P<0.01, P<0.05, respectively). In the carbon tetrachloride + selenium group, the level of triiodothy...

C. McI., a man aged 26 years, a joiner, on August 12. 1953. during the course of a bout of alcoholism. consumed a quantity of carbon tetrachloride in the form of " thawpit." Shortly afterwards he became intensely nauseated, but was unable to vomit for several hours. Thereafter, however, and for the following 48 hours vomiting was intractable. During this time he complained of pain in the chest,...

the present study appraised the hepatoprotective activity of aqueous extract of camellia sinensis leaves and its possible mechanism of action against carbon-tetrachloride-induced liver damage. liver damage was induced by   intraperitoneal administration of equal mixture of carbon tetrachloride   and olive oil (50 % v/v, 0.5 ml/kg ) in male wistar rats (150-220g) once daily for 7 days and the ex...