Organophosphate pesticides are considered as endocrine disruptors that interfere with reproductive functions. The corpus luteum (CL) is a transient endocrine gland that produces progesterone, a crucial hormone for a successful beginning and maintenance of pregnancy. Steroidogenic acute regulatory protein (StAR) facilitates the rate-limiting transfer of cholesterol from the outer mitochondrial m...

BACKGROUND There is considerable variability in the inter-patient response to norepinephrine. Pharmacokinetic studies of dopamine infusion in volunteers and in patients have also shown large variability. The purpose of this study was to define the pharmacokinetics of norepinephrine in septic shock and trauma patients. METHODS After Ethical Committee approval and written informed family consen...

This study examined relationships between some acoustic response properties of 'cluster' recordings (CL) and their constituent single cells (SU) in the auditory cortex obtained from 22 clusters comprised of 63 responsive single units mainly in the anterior tonotopic field of the waking guinea pig. Response parameters included characteristic frequency (CF), threshold (Th) at CF, bandwidth 10 (BW...

Abstract This study aimed to determine if heifers induced puberty had damage in reproductive performance compared with that reach naturally. Nellore (n = 210) were weaned at 8 ± 0.7 mo of age assigned 42 feedlot pens according BW (184 1 kg). The diet was compounded by Tifton-85 haylage (18% CP; 55% TDN) ad libitum and supplement (4g/kg BW; 25% 60% TDN). Puberty growth assessed weekly. At 14 age...

Pre-emergent herbicides are applied directly in the soil or over straw no-till systems and can be retained, reducing product’s availability. The current study characterizes retention of diclosulam diuron forage turnip (FT), buckwheat (BW), black oat (BO) straws. Radiometric techniques evaluated sorption–desorption leaching processes. Spectroscopic microscopic methods characterized chemical morp...

Inorganic lead has been measured in high concentrations in certain streams in Brazil. This study has evaluated the osmoregulatory effects of lead on the native freshwater red crab Dilocarcinus pagei. In order to probe its osmoregulatory and tissue volume regulatory capabilities and how it would be affected by lead, the crab has been submitted to individual and combined salt and chemical stresse...

INTRODUCTION The response to exogenous epinephrine (Ep) is difficult to predict given the multitude of factors involved such as broad pharmacokinetic and pharmacodynamic between-subject variabilities, which may be more pronounced in children. We investigated the pharmacokinetics and pharmacodynamics of Ep, co-administered with milrinone, in children who underwent open heart surgical repair for ...

Genetic selection in primary broiler breeders may modify skeletal structure, possibly impeding semen transfer, and could alter the size and degree of fluctuating asymmetry (FA) of bilateral traits associated with fertility. Hence, we hypothesized specific morphometric traits could predict differential fertility. Sixty primary broiler breeder males from Strains A and B (n = 30/strain) were indiv...

The aims of this study were to develop a population pharmacokinetic model for cefozopran in pediatric patients, and to use this model to evaluate the pharmacodynamics of cefozopran regimens against common bacterial populations. Plasma drug concentration data (110 samples from 31 pediatric patients) were modeled using the NONMEM program. The mean estimate and interindividual variance of the mode...