Bone is formed through the processes of endochondral and intramembranous ossification. In endochondral ossification primary mesenchymal cells differentiate to chondrocytes and then are progressively substituted by bone, while in intramembranous ossification mesenchymal stem cells (MSCs) differentiate directly into osteoblasts to form bone. The steps of osteogenic proliferation, differentiation,...

introduction: the aim of this in vivo study was to determine the effect of demineralized bone matrix (dbm) on alveolar bone repair in type i diabetic rats. materials and methods: this study was carried out on 40 adult (8 weeks-old) albino rats with an average weight of 200-250 grams. the animals were divided into four groups (n=10) as follows: group 1 nondiabetic rats, group 2, 3 and 4 were dia...

Bone like hydroxyapatite (nHAp) was synthesized via an in situ biomimetic process in presence of wheat starch. The effect of polymer concentration alteration on the final structure of nHAp was investigated. Formation of the nHAp at room temperature was confirmed by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR). Size and morphology of the nHAp samples were character...

Mestastatic prostate cancer cells (MPCCs) frequently metastasize to bone, which is a “favorite soil” for colonization and proliferation of MPCCs. Prostate cancer bone mestastasis is tightly associated with tumor-induced bone lesions, most commonly caused from the etiological imbalance between osteoblastic bone formation and osteoclastic bone resorption, and from the anti-tumor immune response. ...

objective(s):various methods for repairing bone defects are presented. cell therapy is one of these methods. bone marrow stromal cells (bmscs) seem to be suitable for this purpose. on the other hand, lots of biomaterials are used to improve and repair the defect in the body, so in this study we tried to produce a similar structure to the bone by the chitosan and hydroxyapatite. materials and me...

bone is formed through the processes of endochondral and intramembranous ossification. in endochondral ossification primary mesenchymal cells differentiate to chondrocytes and then are progressively substituted by bone, while in intramembranous ossification mesenchymal stem cells (mscs) differentiate directly into osteoblasts to form bone. the steps of osteogenic proliferation, differentiation,...

introduction : osteon® is an alloplastic material containing 70% hydroxyapatite and 30% β-tcp. calcitonin, a hormone produced by the thyroid gland, not only prevents bone resorption by reducing both the number and the activity of osteoclasts, but also stimulates bone formation. considering the favorable effects of calcitonin on bone formation, we hypothesized that the addition of calcitonin to ...