Methods Prospective observational study included patients with septic shock admitted to a Tunisian medical -surgical ICU. Each patient was equipped with an arterial and a central venous catheter; patients were also monitored with a pulmonary artery catheter. Treatment for septic shock was standardized according to international recommendations. Microdialysis(MD) catheter was inserted in the fem...

base deficit is a non-respiratory indicator of acid base status. aim of this study is to assess relationship between the base deficit value in immediate post operative period of cabg and valvular heart disease with cardiopulmonary and in hospital outcome of patient. a total of 136 consecutive with cabg and valvular heart disease scheduled in study. 20 variables were determined during the pre-in...

BACKGROUND Our aim was to examine whether serial blood lactate levels could be used as predictors of outcome. METHODS We prospectively studied 44 high-risk, hemodynamically stable, surgical patients. Blood lactate values, mean arterial pressure, heart rate and urine output were obtained at patient admission to the study, at 12, 24 and 48 hours. RESULTS The nonsurvivors (n = 7) had similar b...

STUDY OBJECTIVES To determine whether the lungs of patients with fulminant hepatic failure release lactate, and if so, whether this release relates to systemic lactate concentration or acid base status. Another objective was to examine the accuracy of lactate flux calculations in critically ill patients. DESIGN Prospective observational study. SETTING The ICU of a major teaching hospital. ...

INTRODUCTION The optimal blood glucose target following severe traumatic brain injury (TBI) must be defined. Cerebral microdialysis was used to investigate the influence of arterial blood and brain glucose on cerebral glucose, lactate, pyruvate, glutamate, and calculated indices of downstream metabolism. METHODS In twenty TBI patients, microdialysis catheters inserted in the edematous frontal...

Ten patients with chronic effort angina and coronary artery disease (luminal diameter reduction greater than 75%) were stressed by atrial pacing (140 beats/minutes) before and 15 minutes after intravenous propranolol (mean dose 7.4 mg). Myocardial substrate exchange of oxygen, blood lactate, plasma free fatty acids, citrate, glucose, glutamate, and alanine as well as coronary sinus blood flow w...

Systemic arterial hypertension has been previously suggested to develop as a compensatory condition when central nervous perfusion/oxygenation is compromised. Principal sympathoexcitatory C1 neurons of the rostral ventrolateral medulla oblongata (whose activation increases sympathetic drive and the arterial blood pressure) are highly sensitive to hypoxia, but the mechanisms of this O2 sensitivi...

BACKGROUND Norepinephrine (NE) and epinephrine (EPI) levels are higher in cord arterial blood relative to venous blood, consistent with active mechanisms of placental-maternal clearance. There are no contemporary studies of cord arteriovenous blood levels of sulfated and non-sulfated catechols. AIM To assess the arteriovenous differences in cord blood levels of dopamine (DA), the sulfated cat...

OBJECTIVES The purpose of this study was to test if venous blood drawn from femoral access can be used to estimate the central venous oxygen saturation and arterial lactate levels in critically ill patients. METHODS Bland-Altman analysis and Spearman correlations were used to compare the femoral venous oxygen saturation and central venous oxygen saturation as well as arterial lactate levels a...

Myocardial blood flow has been recognized to be heterogeneous in patients with coronary artery disease. Traditional arterial-coronary sinus sampling methods cannot demonstrate comparable heterogeneity of myocardial metabolism. In this study we used a tracer technique to investigate possible heterogeneity of myocardial lactate metabolism. Twenty-one patients with symptoms of ischemic heart disea...