INTRODUCTION Modern hospital pharmacology insists on assessing each patient's individual characteristics because of their influence on drug pharmacokinetics and pharmacodynamic effect. The study was aimed at evaluating anesthetic doses in patients with benign larynx tumors treated by general endotracheal anesthesia during endoscopic surgery procedures. MATERIAL AND METHODS The study is a part...

bispectral index (BIS) value while undergoing emergency kidney transplantation. Few reports have been made on intraoperative pitfall of BIS value associated with seizure. This case report suggests seizure should be taken into account as a reason for such brief fall of BIS, especially while under general anesthesia or in other specific cases in which clinical signs of seizure are unseen. (Korean...

BACKGROUND Concomitantly recorded Bispectral Index® (BIS) and Entropy™ values sometimes show discordant trends during general anaesthesia. Previously, no attempt had been made to discover which EEG characteristics cause discrepancies between BIS and Entropy. We compared BIS and Entropy values, and analysed the changes in the raw EEG signal during surgical anaesthesia with sevoflurane. METHODS...

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References 1. Triltsch AE, Nestmann G, Orawa H, Moshirzadeh M, Sander M, Große J, Genähr A, Konertz W, Spies CD: Bispectral index versus COMFORT score to determine the level of sedation in paediatric intensive care unit patients: a prospective study. Crit Care 2005, 9:R9-R17 Correction Correction: Bispectral index versus COMFORT score to determine the level of sedation in paediatric intensive c...

Editor’s key points † Automatic feedback control depends on having a reliable, measurable control variable. † An automatic system for closed-loop administration of i.v. anaesthesia drugs was compared with manual control. † Bispectral index and a compound analgesia score were used as the target controls. † Time within excellent (≤10%) and good (11–20%) range of the two targets was better with th...

This paper presents the application of predictive control to drug dosing during anesthesia in patients undergoing surgery. A single-input (Propofol) singleoutput (Bispectral index) model of the patient has been assumed which includes the variable dead time caused by the measurement of the Bispectral index. A set of 12 patient models were studied. Inter-patient variability, varying dead time and...