To broaden the specificity of the Abs recognizing human melanoma-associated Ags (MAAs), we have isolated human single-chain fragment of the V region (scFv) fragments by panning the synthetic phage Ab library (#1) with the human melanoma cell lines S5 and SK-MEL-28. All of the isolated scFv fragments reacted with the mouse mAb defined high molecular weight melanoma-associated Ag (HMW-MAA). scFv ...

We have explored the plastic ability of neuronal precursors to acquire different identities by manipulating their surrounding environment. Specifically, we sought to identify potential signals involved in the specification of forebrain dopaminergic neurons. Here we describe culture conditions under which tyrosine hydroxylase (TH) expression is induced in neuronal precursors, which were derived ...

The goal of this article is to properly define the economic phenomenon business cycle. text rooted in tradition Austrian School Economics, and methodological framework builds on concepts developed by Aristotle Thomas Aquinas. This leads development a few new concepts, such as re-interpretation «inflation» «deflation», re-introduction «imaginary goods» an important social phenomenon. core observ...

Cooperation, Competition, and Risk Attitudes: An Intergenerational Field and Laboratory Experiment The population of most developed societies is ‘graying’. As life expectancy increases and the large baby-boom generation approaches retirement age, this has critical consequences for maintaining a high standard of living and the sustainability of pension systems. In the light of these labor-force ...

Rationality leads people to imitate those with similar tastes but different information. But people who imitate common sources develop correlated beliefs, and rationality demands that later social learners take this redundancy into account. This implies severe limits to rational imitation. We show that (i) in most natural observation structures besides the canonical single-file case, full ratio...

To the Editor: 1 work at an overseas American institution, and there are extended delays in receipt of journals by our medical library. So, it was only a few days ago that I saw the article entitled “Weak Association between HLA-B27 and the Spondylarthropies in Lebanon,” which was published in the February 1997 issue of Arthritis & Rheumatism (1). I would like to draw the attention of the Leban...

The exact process of the human brain and mind information development is still, in many ways, a true mystery. Nonetheless, it seems clear that evolutionary enabled to progress from most basic instinctive aspects evermore advanced levels abstraction, which permitted generation increasingly complex abilities elaborate language. But, how do we believe works? How are able acquire knowledge transmit...

Psychological research suggests that people believe that even in very large samples proportions might depart significantly from the population mean. We model this “non-belief in the Law of Large Numbers” by assuming that a person believes that proportions in any given sample of binary signals might be determined by a rate different than the true rate. In inference, a non-believer attends too li...

A monoclonal antibody against a cell surface ganglioside present on neuroepithelial cells was produced by immunizing mice with the B49 cell line, a clonal line with properties of both neurons and glial cells. The expression of this antigen, designated as D1.l, was analyzed in the developing rat cerebellum. The D1.l antigen was localized by the immunofluorescent staining method to germinal cells...

Indian population is well known for its genetic diversity. Among the numerous endogamous communities, which is restricted very much by custom, marriage and occupation, we have collected a total of 229 individuals from 1996 – 1999 comprising of Parsee, Patels and Vatalia Prajapathi (VP) caste groups. We present here the HLA antigen distribution of these endogamous caste groups and compare their ...