نتایج جستجو برای: atherosclerotic plaque

تعداد نتایج: 51806  

2015
Thomas Lanvin Donald B. Conkey Laurent Descloux Aurelien Frobert Jeremy Valentin Jean-Jacques Goy Stéphane Cook Marie-Noelle Giraud Demetri Psaltis

Coronary artery disease, the main cause of heart disease, develops as immune cells and lipids accumulate into plaques within the coronary arterial wall. As a plaque grows, the tissue layer (fibrous cap) separating it from the blood flow becomes thinner and increasingly susceptible to rupturing and causing a potentially lethal thrombosis. The stabilization and/or treatment of atherosclerotic pla...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2011
Omry Koren Aymé Spor Jenny Felin Frida Fåk Jesse Stombaugh Valentina Tremaroli Carl Johan Behre Rob Knight Björn Fagerberg Ruth E Ley Fredrik Bäckhed

Periodontal disease has been associated with atherosclerosis, suggesting that bacteria from the oral cavity may contribute to the development of atherosclerosis and cardiovascular disease. Furthermore, the gut microbiota may affect obesity, which is associated with atherosclerosis. Using qPCR, we show that bacterial DNA was present in the atherosclerotic plaque and that the amount of DNA correl...

Journal: :Circulation 1999
J J Badimon M Lettino V Toschi V Fuster M Berrozpe J H Chesebro L Badimon

BACKGROUND Plaque disruption and subsequent thrombus formation lead to acute coronary syndromes and progression of atherosclerotic disease. Tissue factor (TF) appears to mediate plaque thrombogenicity. Tissue factor pathway inhibitor (TFPI) is the major physiological inhibitor of TF. This study analyzes the role of TF on thrombogenicity of disrupted human atherosclerotic plaques and the therape...

Journal: :European heart journal 2014
Xu-Ping Wang Wei Zhang Xiao-Qian Liu Wen-Ke Wang Fei Yan Wen-Qian Dong Yun Zhang Ming-Xiang Zhang

AIMS The aim of this study was to investigate the effect of Arginase I (ArgI) on plaque stabilization in unruptured atherosclerotic plaque and explore its mechanism. METHODS AND RESULTS The atherosclerotic plaque model was established in New Zealand rabbits by balloon injury of abdominal arteries and a high cholesterol (1%) diet. Arginase I overexpression reduced the content of macrophages an...

Journal: :Current pharmaceutical design 2012
E Mendizabal G Ruiz Theodore G Papaioannou Manolis Vavuranakis Christodoulos Stefanadis Morteza Naghavi Ioannis A Kakadiaris

Atherosclerotic cardiovascular disease (CVD), primarily manifested as heart attacks and strokes, remains the main cause of death in the developed countries and is rapidly increasing in the developing world. Early detection and aggressive treatment of hidden (asymptomatic) atherosclerotic plaques that cause heart attack or stroke are most needed. However, existing clinical tools are not sufficie...

Journal: :Arteriosclerosis, Thrombosis, and Vascular Biology 1998

Journal: :Journal of Internal Medicine 2015

Journal: :Arteriosclerosis, Thrombosis, and Vascular Biology 2015

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