OBJECTIVES To compare the efficacy and safety of artemisinin combination therapies for the treatment of uncomplicated falciparum malaria in Uganda. DESIGN Randomized single-blind controlled trial. SETTING Tororo, Uganda, an area of high-level malaria transmission. PARTICIPANTS Children aged one to ten years with confirmed uncomplicated P. falciparum malaria. INTERVENTIONS Amodiaquine + ...

BACKGROUND Artemether-lumefantrine is currently the most widely recommended treatment of uncomplicated malaria. Lopinavir-based antiretroviral therapy is the commonly recommended second-line HIV treatment. Artemether and lumefantrine are metabolised by cytochrome P450 isoenzyme CYP3A4, which lopinavir/ritonavir inhibits, potentially causing clinically important drug-drug interactions. METHODS...

The Republic of the Congo adopted artemisinin-based combination therapies (ACTs) in 2006: artesunate-amodiaquine and artemether-lumefantrine as the first-line and second-line drugs, respectively. The baseline efficacy of artemether-lumefantrine was evaluated between March and July 2006 in Brazzaville, the capital city of Congo. Seventy-seven children aged between 6 months and 10 years were enro...

OBJECTIVE To compare the efficacy of artemether and quinine in the treatment of severe malaria in hospitalized children. STUDY DESIGN Open randomized trial. SETTING Pediatric ward of a tertiary care center. METHODS All children admitted with clinical manifestations of severe malaria (as per WHO criteria) and asexual forms of Plasmodium falciparum demonstrated on peripheral smear were rand...

Solid dispersions of artemether and polyethylene glycol 6000 (PEG6000) were prepared in ratio 12 : 88 (group-1). Self-emulsified solid dispersions of artemether were prepared by using polyethylene glycol 6000, Cremophor-A25, olive oil, Transcutol, and hydroxypropyl methylcellulose (HPMC) in ratio 12 : 75 : 5 : 4 : 2 : 2, respectively (group-2). In third group, only Cremophor-A25 was replaced wi...

OBJECTIVES To study the fasciocidal properties of artesunate and artemether in the rat model and in vitro. METHODS Adult Fasciola hepatica were exposed in vitro to 1, 10 and 100 microg/mL of artesunate, artemether and dihydroartemisinin for 72 h. Female Wistar rats were administered a single oral dose of artesunate and artemether (100-400 mg/kg) commencing 3 or 10-14 weeks post-infection and ...

BACKGROUND The burden of Plasmodium vivax infections has been underappreciated, especially in southeast Asia where chloroquine resistant strains have emerged. Our aim was to compare the safety and efficacy of dihydroartemisinin-piperaquine with that of artemether-lumefantrine in patients with uncomplicated malaria caused by multidrug-resistant P falciparum and P vivax. METHODS 774 patients in...

results in this case, the protoscolicidal effect of artemether and its combinations was significantly (p < 0.05) higher than other groups; the maximum protoscolicidal effect was found with 200 μg/ml of artemether after 4 days whereas albendazole killed protoscoleces on the 7th day post-incubation. surprisingly, the incubation of protoscoleces with artemisinine exhibited promising results, as on...

1. van Hensbroek MB, Onyiorah E, Jaffar S et al. A trial of artemether or quinine in childrenwith cerebralmalaria.NEngl JMed1996; 335: 69–75 2. Hien TT, Day NPJ, Phu NH et al. A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria. N Engl J Med 1996; 335: 76–83 3. Karunajeewa HA, Mueller I, Senn M et al. A trial of combination antimalarial therapies in c...

Schistosomiasis continues to rank – following malaria – at the second position of the world’s parasitic diseases in terms of the extent of endemic areas and the number of infected people. There is yet no vaccine available and the current mainstay of control is chemotherapy with praziquantel used as the drug of choice. In view of concern about the development of tolerance and/or resistance to pr...