In-vitro drug sensitivity tests were performed on Philippine isolates of Plasmodium falciparum between 1991 and 1993, using the radioisotope microdilution method. The success of the tests varied significantly with the level of parasitaemia, the source of the strains, the period that elapsed before culturing, and the detectable concentrations of antimalarials in the blood. There was a significan...

1. van Hensbroek MB, Onyiorah E, Jaffar S et al. A trial of artemether or quinine in childrenwith cerebralmalaria.NEngl JMed1996; 335: 69–75 2. Hien TT, Day NPJ, Phu NH et al. A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria. N Engl J Med 1996; 335: 76–83 3. Karunajeewa HA, Mueller I, Senn M et al. A trial of combination antimalarial therapies in c...

In India, the first confirmed report of chloroquine resistance in P. falciparum was reported in 1973. Since then there has been a rise in resistance to chloroquine in Plasmodium falciparum and vivax as also to pyrimethamine sulphadoxine group of drugs. Resistance to artemisinin and its derivatives has not been documented in India except for isolated case reports. In a multicentric study of arte...