OBJECTIVE To determine the therapeutic efficacy of adjuvant use of voriconazole, 1%, eyedrops in the treatment of refractory fungal keratitis. METHODS A prospective open-label trial was conducted to determine voriconazole levels obtained in human aqueous humor after administration of a 1% solution, preserved with 0.01% benzalkonium chloride, every 6 hours for 3 days, or hourly for 4 doses. Te...

The distribution of cyclosporin A (CsA) in the blood, saliva, tears, aqueous humour, vitreous, and cerebrospinal fluid has been studied after oral treatment with 5 mg/kg/day of CsA or application of 2% CsA eye drops in olive oil solution. After oral treatment all patients had high CsA levels in blood. Measurable levels of CsA were also found in the saliva and tears. Patients without any intraoc...

THE unsatisfactory state of our knowledge regarding the effect of cortisone on capillary permeability has been discussed in a previous paper (Duke-Elder and Ashton, 1951). It was there noted that Leopold and others (1951), injecting fluorescein intravenously in rabbits and estimating its concentration in the aqueous humour, observed no delay in the appearance of the dye in the anterior chambers...

PURPOSE To investigate the penetration of tacrolimus to the aqueous and serum after topical and oral administration. METHODS Thirty Wistar rats were divided into three groups. In the first group (n = 12), a single dose of 0.3 % isotonic tacrolimus solution was applied topically to the rat eyes. The second group (n = 12), received 0.1 mg/kg/day tacrolimus for three days. In control group (n = ...

Exogenous corticosteroids (dexamethasone, cortisol) inhibit the adrenal secretion of corticosterone in the rabbit and decrease the concentration of corticosterone in aqueous humour, increase glycaemia and cause a rise in glucose concentration in the aqueous. Except for a slight rise 16 h after the corticosteroid administration no effect on plasma or aqueous content of total protein was observed...

purpose: to evaluate the effect of early aqueous suppressants initiation on ahmed glaucoma valve success rate. methods: in this randomized clinical trial, a total of 94 eyes of 94 patients with refractory glaucoma were enrolled. the eyes were randomly selected into 2 groups. in group 1 (n=47), patients received early topical combination of timolol-dorzolamide twice daily after ahmed glaucoma va...

purpose: to evaluate the diagnosis of intraocular tuberculosis (tb) with polymerase chain reaction (pcr) and to report 13 cases of presumed intraocular tb. methods: of 168 patients with uveitis, 13 patients (7.74%) had criteria for intraocular tb (tb group). thirteen patients with non-tb uveitis were randomly selected as the control group. samples for pcr were obtained from the aqueous humor. s...

The juxtacanalicular connective tissue (JCT) is widely believed to generate the bulk of aqueous humor outflow resistance, while the pores of the inner wall endothelium are thought to generate at most 10% of this resistance in humans. However, the hydrodynamic interaction of these two components of the aqueous outflow system, which arises because of their spatial proximity, has only recently bee...

The aim of this study has been to determine whether eye chambers constitute part of the normal migratory pathway of naive CD4+ and CD8+ T cells in mouse and if natural CD4+CD25+Foxp3+ and CD8+CD25+Foxp3+ regulatory T cells are present within these eye compartments. To this aim, the cells obtained from aqueous humor (AH) of normal mice were phenotyped in terms of the expression CD4, CD8, CD25, C...

Both intraocular pressure and aqueous humour turnover rate were determined at intervals over three months in three females in order to investigate whether a correlation existed between these variables and the menstrual cycle. Not only was there a lack of correlation between intraocular pressure or aqueous humour flow rate and menses but intraocular pressure and aqueous humour flow rate were als...