BACKGROUND Oldenlandia affinis, commonly called 'kalata-kalata', a versatile plant used locally to treat malaria fever in some parts of sub-Saharan Africa was investigated for anti-plasmodial and anti-inflammatory activities. OBJECTIVE The study was designed to evaluate the antiplasmodial as well as anti-inflammatory activities of whole extract and cyclotide-rich fraction of Oldenlandia affin...

anopheles stephensi is one of the main vectors of malaria in the world including south of iran. three geographical populations for an. stephensi have been defined, based on egg morphology. the aim of the current study is determining the ability of different geographical populations of an. stephensi in the transmission of plasmodium berghei using anka strain of this parasite. four geographical p...

Objective. The study was designed to determine the efficacy of combined Amodiaquine and Ciprofloxacin in plasmodiasis therapy. Method. The in vivo antiplasmodial effect of different dosage levels of Amodiaquine, Ciprofloxacin, and their combinations against Plasmodium berghei berghei was evaluated using Swiss albino mice. Results. Amodiaquine (a known antiplasmodial agent) had a fairly signific...

Triple antimalarial combination therapies may overcome the emergence of drug resistance. Sulfadoxine/pyrimethamine (S/P) is an drug. Clindamycin (C) has potential antiplasmodial effect. This study assessed whether activity S/P can be augmented by C on Plasmodium berghei-infected mice. Adult Swiss albino mice (25-30g) were grouped and infected with berghei. The orally treated daily (21.4/10.7 mg...

Natural product-derived drugs exemplified by quinine, isolated from South American Cinchona species and artemisinin discovered in China are of immense importance for the treatment of malaria. Although malaria parasites resistant to artemisinin have not yet been found in malaria patients, the need for new antimalarial agents remains. The burden of malaria is heaviest in Africa where over a milli...

Launaea taraxacifolia and Amaranthus viridis used by people of Western Africa in the treatment of malaria and related symptoms were assessed for their antiplasmodial value against the chloroquine sensitive strain of Plasmodium berghei. Crude extracts (200 mg/kg) and chloroquine (5 mg/kg) were administered to different groups of Swiss mice. The percentage of parasitemia, survival time, and haema...

Abstract Background Kniphofia foliosa is a flamboyant robust perennial herb which has dense clumps and tick upright rhizomes with leaves at the base. In Ethiopia, it several vernacular names including Abelbila , Ashenda Amelmela Yeznjero Ageda Shemetmetie Yezinjero . The plant endemic to Ethiopian highlands, where its are traditionally used for treatment of malaria, abdominal cramps wound heali...

Abstract Background Piliostigma reticulatum is a plant traditionally used to treat malaria, smallpox, neuralgia, dysentery, diarrhea, and rheumatism in Northern Nigeria. There no scientific evidence support the antimalarial activity of this plant. This work aims investigate vivo antiplasmodial methanol leaf extract (MPR) mice, infected with NK65 chloroquine-sensitive Plasmodium berghei . The or...

OBJECTIVES In an attempt to discover new natural active extracts against malaria parasites, the present study evaluated the antiplasmodial properties of selected plants based on Iranian traditional medicine. MATERIALS AND METHODS Ten plant species found in Iran were selected and collected based on the available literature about the Iranian traditional medicine. The methanolic extracts of thes...

The heme peroxidase HPX15 is an evolutionary conserved anopheline lineage-specific gene. Previously, we found that this gene is present in the genome of 19 worldwide distributed different species of Anopheles mosquito and its orthologs are absent in other mosquitoes, insects, or human. In addition, 65-99% amino acid identity among these 19 orthologs permitted us to hypothesize that the function...