Laboratory tests showed a slightly increased white blood cell count (8,800/mm 3 ) and increased C-reactive protein (11.13 mg/dl). Other blood tests including liver enzymes and renal function were within normal ranges. The urine was negative for Legionella pneumophila and Streptococcus pneumoniae antigen tests. Further laboratory investigation, including immunoglobulin levels, rheumatoid factor,...

Churg-Strauss syndrome (CSS) is a small-vessel necrotizing vasculitis typically characterized by asthma, lung infiltrates, extravascular necrotizing granulomas and hypereosinophilia. Cardiac disease is a major contributor to disease-related death in CSS. We describe a 38-year-old man with late-onset asthma, allergic rhinosinusitis, and high extravascular and peripheral blood eosinophilia, who p...

While antineutrophil cytoplasmic antibody (ANCA) positivity has been documented in some patients with postinfectious glomerulonephritis (PIGN) and is associated with more severe disease, antiphospholipid antibodies (APA) are not known to be a common occurrence. We describe a child with severe acute kidney injury who was noted to have prolonged positivity of both ANCA and APA; a renal biopsy sho...

Dear Editor, A 42-year-old man presented with a 4-week history of erythematous, maculopapular rash over his whole body (Fig.1), shortness of breath and generalised lymphadenopathy for 1 week. Clinical examination showed erythroderma with multiple lymph nodes in the cervical, axillary and groin areas. The lymph nodes were firm, mobile, non tender and were not attached to underlying structures. T...

Background: Inflammatory bowel disease unclassified (IBDU) is considered to be an aberrant immune response with loss of tolerance to many antigens. Objective: This paper tries to address whether there is any value to test for auto-antibodies in such patients. Methods: 60 patients with inflammatory bowel disease unclassified participated in the study. Auto-antibodies to nuclear antigen, intestin...