Fingolimod (FTY720), a novel class of sphingosine 1-phosphate receptor modulators, has received special interest among ophthalmologists, particularly given that oral administration of FTY720 has proven to effectively treat corneal graft rejection in animal models. However, no studies have examined the performance of FTY720 as an ophthalmic solution in reducing corneal rejection in high-risk cor...

introduction epithelial rejection typically begins in a linear pattern from the periphery of the graft and progresses centripetally. here in, we reported a patient with a new presentation of corneal epithelial graft rejection. case presentation a 23-year-old man presented with blurred vision two months after penetrating keratoplasty. conclusions slit lamp examination revealed sharply demarcated...

We report a case of rapid resolution of Coronary Artery Spasm (CAS) and improvement of systolic heart failure by antirejection therapy with methylprednisolone in the setting of acute Orthotopic Heart Transplant (OHT) rejection. The proposed mechanism of action is reduced microvascular inflammation from steroid therapy resulting in enhanced vasomotor response, resolution of coronary artery spasm...

BACKGROUND Costimulation blockade with antibodies directed against human CD40 and CD86 leads to prolonged kidney allograft survival in rhesus monkeys, but fails to induce permanent graft acceptance. We have tested whether costimulation blockade is more effective after peripheral T-cell ablation with antithymocyte globulin (ATG), with the aim to remove already primed autoreactive cells present i...

purpose: to investigate the efficacy of topical cyclosporine a 2% in treating and preventing recurrent graft rejection episodes after penetrating keratoplasty (pkp) in patients with history of previous rejection episodes. methods: in this clinical trial, eligible pkp patients were randomly given topical cyclosporine a 2% or placebo in addition to a standard corticosteroid regimen for an episode...

BACKGROUND The proportion of cardiac transplant recipients with preexisting sensitization to HLA alloantigens has been increasing. Sensitization prolongs duration to obtaining a donor and predicts poorer long-term allograft survival because of increased risk of cellular rejections. We investigated the effect of cyclophosphamide pulse therapy in sensitized cardiac allograft recipients. METHODS...

BACKGROUND Although the utility of antibody induction therapy has been demonstrated in clinical trials, the ideal regimen to use based on patient risk factors has not been fully elucidated. The objectives of this study were to determine the impact of either anti-interleukin-2 receptor antibodies (IL-2RA) or thymoglobulin induction therapies versus no induction therapy on acute rejection rates a...