نتایج جستجو برای: anaplastic lymphoma kinase

تعداد نتایج: 333698  

2017
Severine Cao Vinod E. Nambudiri

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that has been implicated in the pathogenesis of a variety of neoplasms. As suggested by its name, ALK was first described as part of a translocation product in cases of anaplastic large-cell lymphoma, with other genetic and cytogenetic ALK mutations subsequently coming to attention in the development of many other hematologic and so...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2015
Ryohei Katayama Christine M Lovly Alice T Shaw

The anaplastic lymphoma kinase (ALK) receptor tyrosine kinase was initially discovered as a component of the fusion protein nucleophosmin (NPM)-ALK in anaplastic large-cell lymphoma (ALCL). Genomic alterations in ALK, including rearrangements, point mutations, and genomic amplification, have now been identified in several malignancies, including lymphoma, non-small cell lung cancer (NSCLC), neu...

Journal: :Hematological Oncology 2023

Background: Platelet-derived growth factor receptor (PDGFR) is expressed in nucleophosmin–anaplastic lymphoma kinase (NPM-ALK) positive anaplastic large cell lymphomas (ALCL ALK+). Our previous preclinical research suggested that PDGFR blockade by the Abl/c-Kit/PDGFR inhibitor imatinib could be an effective treatment strategy for ALCL ALK+. A young indicator patient whose cells and who failed t...

Journal: :Neurology - Neuroimmunology Neuroinflammation 2020

Journal: :American Journal of Clinical Oncology 2019

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