BACKGROUND Olopatadine hydrochloride ophthalmic solutions are treated for allergic conjunctival diseases that are a selective histamine H1 receptor antagonist and an inhibitor of the release of mediators including histamine from the human mast cells. Substance P (SP) levels are increased in tears of patients with allergic conjunctivitis. However, little is known about the regulation of SP relea...

Tears from patients with chronic allergic conjunctivitis were analyzed with flow cytometry to determine the function of the T lymphocyte-related immunological reactions in the disease pathogenesis. Twenty-eight patients and 22 normal volunteers were studied; tears were obtained with capillary tubes. T helper/T suppressor ratios and the percentages of HLA DR+, CD23+, and CD3+ cells were signific...

Therapeutic Area: Ophthalmology Inflammatory diseases of the ocular surface, including allergic conjunctivitis (AC) Mechanism of action: Anti-inflammatory and immuno-modulator Planned indication: Treatment of signs and symptoms of allergic conjunctivitis Patent protection: License from Zalicus, Patents expire in November 2026 (without patent extension) US: patented EU: patent pending Route of a...

OBJECTIVES Stress is considered a causal factor in many diseases, allergic disease being one of them. The prevalence of allergic disease is increasing in Korea, but the relationship between allergic symptoms and stress is not empirically well known. We aimed to evaluate the relationship between allergy-related symptoms and stress in children and adolescents. METHODS We investigated 698 childr...