Serum creatine kinase, lactate dehydrogenase, aspartate and alanine transaminases, and aldolase were determined in 41 hospital inpatients with haemophilia or Christmas disease and no significant differences from the normal ranges were found.(3) Levels of these enzymes in a further 10 such patients who had sustained muscle haematomata were determined: in all of these there was a consistent rise ...

background the current organ shortage has prompted the use of marginal organs. we conducted this retrospective study to present our experience with transplanting deceased donor livers with elevated levels of serum transaminases and to explain whether elevated levels of serum transaminases in donors affect allograft function and survival of the recipients. methods data of deceased donor livers a...

Severe acute respiratory syndrome (SARS) is a newly emerged infectious disease with a significant morbidity and mortality. The major clinical features include persistent fever, chills/rigor, myalgia, malaise, dry cough, headache, and dyspnoea. Older subjects may present without the typical febrile response. Common laboratory features include lymphopenia, thrombocytopenia, raised alanine transam...

We report representative serum enzyme changes after cardiac transplantation in 20 patients receiving post-transplant therapy with cyclosporine. In general, the changes resembled those after acute myocardial infarction or coronary artery bypass surgery, but were more prolonged. Cardiac biopsy or episodes of cardiac rejection did not usually alter serum enzyme activities. Cyclosporine A toxicity ...

The existence of a glutamic acid racemase activity in Lactobacillus arabinosus has been reported by Narrod and Wood (1) and by Ayengar and Roberts (2). As has been pointed out by Meister (3) these observations with dried cell preparations would not exclude a mechanism for glutamic acid racemization in which alanine racemase is coupled with n-glutamic acid-nalanine transaminase and n-glutamic ac...

drogenase in normal human skin. In comparison with glutamate dehydrogenase, which catalyzes reversible oxidative deamination, the transaminases catalyze transfer of amino groups, usually from an amino acid to a ketoacid, without net loss of nitrogen. In other words, transamination represents the intermolecular exchange of amino nitrogen. Transamination plays a significant role in metabolism by ...

It has now been clearly established that pyridoxal phosphate serves as the coenayme of many transaminases. Several lines of evidence have indicated that the coenzyme acts alternately as acceptor and donar of amino groups, shuttling between the aldehydic (pyridoxal phosphate) and amino (pyridoxamine phosphate) forms (2-11). However, a detailed study of the kinetics of the transaminase reaction w...

PH1 (primary hyperoxaluria type 1) is a severe inborn disorder of glyoxylate metabolism caused by a functional deficiency of the peroxisomal enzyme AGXT (alanine-glyoxylate aminotransferase), which converts glyoxylate into glycine using L-alanine as the amino-group donor. Even though pre-genomic studies indicate that other human transaminases can convert glyoxylate into glycine, in PH1 patients...

BACKGROUND Severe anoxic brain injury can lead to prolonged episodes of status dystonicus. Sustained dystonia can result in skeletal muscle breakdown and elevation of serum transaminases, which can initially be confused with polypharmacy-related hepatotoxicity or an underlying metabolic condition. PATIENT We present a 19-month-old boy who sustained a severe anoxic brain injury in the setting ...