Leukemia cutis (LC) is defined as a neoplastic leukocytic infiltration of the skin. Few clinical studies are available on recent trends of LC in Korea. The purpose of this study was to analyze the clinical features and prognosis of LC in Korea and to compare findings with previous studies. We performed a retrospective study of 75 patients with LC and evaluated the patients' age and sex, clinica...

Although leukocytes from all 13 acute lymphoblastic leukemia patients examined had high terminal deoxynucleotidyl transferase (terminal transferase) activity (20 to 100 units/mg of cellular DNA, where 1 unit equals 1 nmole of nucleotide polymerized in 1 hr) and those from 21 acute myelocytic leukemia patients had low terminal transferase activity (0.2 to 2 units/mg of cellular DNA), the bone ma...

The decision to operate for abdominal pain in patients with leukopenia can be exceedingly difficult. Surgical exploration may be the only effective way to differentiate acute appendicitis from other causes, but it involves considerable risk of infectious complications due to immunosuppression. Leukemic patients, who presented significant RLQ pain, had been indicated for operation, despite havin...

ECG, electrocardiogram; CT, computed tomography; M1, acute myeloid leukemia without differentiation; WBC, white blood cells; WHO, World Health Organization; CK-MB, creatine kinase–myocardial band; CBC, complete blood count; APL, acute promyelocytic leukemia; AML, acute myelocytic leukemia; ALL, acute lymphocytic leukemia; CD, cluster of differentiation; HLA-DR, human leukocyte antigen–D related...

many studies have shown the clinical importance of cd7 expression in aml patients. to evaluate the clinical importance and response to chemotherapy in cd7 positive aml, this study was conducted. from the patients, 76 cases were studied during 3 years. in 3 years of this study 70.5 percent of cd7 positive and 89.6 percent of cd7 negative patients achieved complete remission with no significant d...

Recently, it has been shown that the homozygous deletion of the cyclin-dependent kinase-4 inhibitor (CDK4I;p16) gene, which is mapped to chromosome 9p21, is frequently observed in a wide spectrum of human cancers, including leukemias. Therefore, the CDK4I gene is thought to be a putative tumor-suppressor gene. We report here that both alleles of the CDK4I gene were completely or partially delet...

The sialic acid content of erythrocytes from healthy individuals of different blood types and of patients with known hematological disorders has been determined. The sialic acid was completely released enzymatically with sialidase and quantitated by the thiobarbituric acid method. The sialic acid content of erythrocytes was constant irrespective of ABO blood type, or anticoagulant used; viz, 0....

A 10-year-old boy was admitted with left leg pain and fever of 38.9°C. The initial clinical impression was cellulitis. Laboratory findings included hemoglobin of 5 gjdl and white blood cell count of 206,OOOjmma The spleen was enlarged and multiple cervical lymph nodes were palpable. Bone marrow pathology was interpreted as acute myelocytic leukemia. The child was treated with antibiotics , but ...

A monoclonal antibody specific for a common acute lymphoblastic leukemia (ALL) antigen has been generated and characterized. This antibody (J-5) is reactive with leukemic cells from most patients with non-T-cell ALL and some patients with chronic myelocytic leukemia in blast crisis. J-5 antibody is not reactive with leukemic cells from patients with either T-cell ALL, chronic lymphocytic leukem...