The space radiation environment can have serious effects on spacecraft electronics. For example, accumulated damage from electron and proton exposure will limit system endurance. Transient effects from individual high-energy protons or cosmic rays can disrupt system operation, perhaps irreversibly. Of particular importance in assessing the impact of the space radiation on electronic devices are...

Genome maintenance is ensured by a variety of biochemical sensors and pathways that repair accumulated damage. During mitosis, the mechanisms that sense and resolve DNA damage remain elusive. Studies have demonstrated that damage accumulated on lagging chromosomes can activate the spindle assembly checkpoint. However, there is little known regarding damage to DNA after anaphase onset. In this s...

Circulating alpha 1-antitrypsin is synthesized primarily in the liver and secreted into the bloodstream, where it serves as the major protease inhibitor. The PiZ variant of alpha 1-antitrypsin is associated with decreased levels of the protein in sera as a result of its retention within hepatocytes. Homozygosity for the variant allele predisposes individuals to the development of pulmonary emph...

Objective To examine the relation between childhood adversity, the role of school performance, and childhood psychopathology and the risk of suicide.Design Cohort study of register based indicators of childhood adversity (at ages 0-14) including death in the family (suicide analysed separately), parental substance abuse, parental psychiatric disorder, substantial parental criminality, parental ...

Helicobacter pylori (H. pylori) is a pathogen contributing to peptic inflammation, ulceration, and cancer. A crucial step in the pathogenic sequence is when the bacterium first interacts with gastric tissue, an event that is poorly understood in vivo. We have shown that the luminal space adjacent to gastric epithelial damage is a microenvironment, and we hypothesized that this microenvironment ...

Diabetic retinopathy is a complication of type 2 diabetes resulting from long-term accumulated damage to retinal blood vessels and one the life-threatening complications most common cause acquired blindness in adults it affects 93 million people worldwide.

This paper describes how the fusion of two different prognostic approaches produces a result that is more accurate and has more narrow uncertainty bounds than either approach alone. The fused prognostic estimate can be calculated by using both a physics-based as well as a datadriven approach. The individual approaches can have a plurality of input sources such as component properties (e.g., mat...

Indentation tests were used for early detection of deformation-induced damage Inconel 718. Damage was produced in a controlled manner using specially designed specimens with variable width the gage part. Static tension, LCF, and HCF performed to induce material damage. Accumulated plastic strain intensity as reference measure Detection progress its phase based on use strain-hardening cross-effe...

This work addresses the instability in asynchronous data parallel optimization. It does so by introducing a novel distributed optimizer which is able to efficiently optimize a centralized model under communication constraints. The optimizer achieves this by pushing a normalized sequence of first-order gradients to a parameter server. This implies that the magnitude of a worker delta is smaller ...