how to cite this article: inaloo s, haghbin s. multiple sclerosis in children. iran j child neurol. 2013 spring;7(2):1-10.   multiple sclerosis (ms) is the most important immune-mediated demyelinated disease of human which is typically the disease of young adults. a total of 4% to 5% of ms population are pediatric. pediatric ms is defined as the appearance of ms before the age of sixteen. about...

PPARs are members of the steroid hormone nuclear receptor superfamily and play an important role in the regulation of lipid metabolism, energy balance, artherosclerosis and glucose control. Recent studies suggest that they play an important role in regulating inflammation. This review will focus on PPAR-alpha regulation of the immune response. We describe how PPAR-alpha regulates differentiatio...

Glutamate-mediated excitotoxicity and neurodegeneration have been shown as pathophysiological hallmarks of multiple sclerosis (MS) and other autoimmune inflammatory CNS disorders. N‑Methyl‑D‑Aspartate (NMDA) receptors play a pivotal role in the mediation of neuronal glutamate excitotoxicity leading to cellular damage and apoptotic cell death. Current treatment approaches targeting glutamate exc...

multiple  sclerosis  (ms) is  an  autoimmune  multifactorial  degenerative  disease  with detrimental affliction on central nervous system. mhc class i chain- related genea,b(mica and micb) are nonclassical human leukocyte antigens that can affect on some diseases and also on transplantation. the purpose of this study was to evaluate the mica and micb mrna expression in multiple sclerosis patie...

Multiple sclerosis is an inflammatory demyelinating disease of the CNS associated with T cells autoreactive for myelin components. In this study, we analysed the T-cell receptor (TCR) usage of the variable beta (Vbeta) chain transcriptome in the blood of multiple sclerosis patients at various stages of the disease using a global and quantitative comparison of the complementarity-determining reg...

BACKGROUND High content immune profiling in peripheral blood may reflect immune aberrations associated with inflammation in multiple sclerosis (MS) and other autoimmune diseases affecting the central nervous system. METHODS AND FINDINGS Peripheral blood mononuclear cells from 46 patients with multiple sclerosis (MS), 9 patients diagnosed with relapsing remitting MS (RRMS), 13 with secondary p...

Corticosteroids are standard treatment for patients with multiple sclerosis experiencing acute relapse. Because dyspeptic pain is a common side effect of this intervention, patients can be given a histamine receptor-2 antagonist, proton pump inhibitor or antacid to prevent or ameliorate this disturbance. Additionally, patients with multiple sclerosis may be taking these medications independent ...