نتایج جستجو برای: 6 hydroxy dopamine

تعداد نتایج: 1020826  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1996
M Laruelle A Abi-Dargham C H van Dyck R Gil C D D'Souza J Erdos E McCance W Rosenblatt C Fingado S S Zoghbi R M Baldwin J P Seibyl J H Krystal D S Charney R B Innis

The dopamine hypothesis of schizophrenia proposes that hyperactivity of dopaminergic transmission is associated with this illness, but direct observation of abnormalities of dopamine function in schizophrenia has remained elusive. We used a newly developed single photon emission computerized tomography method to measure amphetamine-induced dopamine release in the striatum of fifteen patients wi...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1996
B H Westerink H F Kwint J B deVries

Receptor-specific compounds were applied by retrograde microdialysis to the ventral tegmental area (VTA) of the rat brain. The effect of the intrategmental infusions on extracellular dopamine in the ipsilateral nucleus accumbens were recorded with a second microdialysis probe. Intrategmental infusion of muscimol (10-40 microM) or baclofen (50 microM) decreased extracellular dopamine in the nucl...

2014
Aude Retailleau Thomas Boraud

Spatial learning has been recognized over the years to be under the control of the hippocampus and related temporal lobe structures. Hippocampal damage often causes severe impairments in the ability to learn and remember a location in space defined by distal visual cues. Such cognitive disabilities are found in Parkinsonian patients. We recently investigated the role of dopamine in navigation i...

Journal: :Bioorganic & medicinal chemistry 2010
Gianfabio Giorgioni Dario Ambrosini Cristian Vesprini Alan Hudson Cinzia Nasuti Antonio Di Stefano Piera Sozio Osele Ciampi Barbara Costa Claudia Martini Antonio Carrieri Giuseppe Carbonara Christoph Enzensperger Maria Pigini

Based on the well known biological versatility of the imidazoline nucleus, we prepared the novel derivatives 3a-k inspired by 2-BFI scaffold to assess imidazoline molecules as D(2)-like dopamine receptor ligands. Conservative chemical modifications of the lead structure, such as the introduction of an hydroxy group in the aromatic ring alone or associated with N-benzyl substitution, provided pa...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1994
K F Schmidt M Kruse H Hatt

The patch-clamp technique in combination with a fast liquid filament application system was used to study the effect of dopamine on the glutamate receptor desensitization in horizontal cells of the perch (Perca fluviatilis). Kinetics of ligand-gated ion channels in fish horizontal cells are modulated by dopamine. This modulation is presumably mediated by a cAMP-dependent protein phosphorylation...

Journal: :Behavioral neuroscience 2009
Won Yung Choi Cecile Morvan Peter D Balsam Jon C Horvitz

Experimentally induced and parkinsonian disruptions in dopamine (DA) transmission are associated with motor abnormalities that include a reduced likelihood of behavioral response initiation and an increased duration of executed responses. Here we investigated the dopamine receptor subtypes involved in regulating these two aspects of behavior. We examined the effects of D1 family (D1/D5) antagon...

Journal: :Progress in neuro-psychopharmacology & biological psychiatry 2002
Alessandra Ottani Francesca Ferrari Daniela Giuliani

(1) The present study was performed to assess the effects exerted by the cannabinoid (CB) agonist, (-)11-hydroxy-delta8-tetrahydrocannabinol-dymethylheptyl (HU 210; 12.5-50 microg/kg ip), on rodent behavioural tests involving dopamine (DA) transmission; in comparison, the DA D2 antagonist, S(-)-3-chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxy-benzamide hydrochloride ((-)e...

Journal: :Russian Journal of Physical Chemistry B 2022

Nine compounds are studied for antioxidant activity, including those from the class of catecholamines containing 3,4-hydroxyphenyl (catechol) as a common structural fragment, which imparts properties to in reactions hydrocarbon substrate oxidation. The antiradical activity is determined by chemiluminescent method interception peroxyl radicals model reaction initiated oxidation ethylbenzene (RH)...

Journal: :the iranian journal of pharmaceutical research 0
siamak reyhani-rad science and research branch, islamic azad university, tehran, iran. alireza nayebi department of pharmacology and toxicology, faculty of pharmacy, tabriz university of medical sciences. drug applied research center, tabriz university of medical sciences. javad mahmoudi neurosciences research center (nsrc), tabriz university of medical sciences, tabriz iran. morteza samini science and research branch, islamic azad university, tehran, iran. vahab babapour science and research branch, islamic azad university, tehran, iran.

we have shown that buspirone, a partial agonist of 5-hydroxytryptamine 1a (5-ht1a) receptors, improves motor dysfunctions induced by 6-hydroxydopamine (6-ohda) and haloperidol in rats. the present work extends these findings by investigating the role of 5-ht1a receptors on catalepsy-like immobilization in rats, a model of parkinson’s disease. catalepsy was induced by unilateral infusion of 6-oh...

Journal: :Acta Crystallographica Section E Structure Reports Online 2009

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