The main histological and histochemical changes in the rat's liver tissue induced by intraperitoneal injection of 5-FU were investigated in this study. Twelve adult female rats were divided into two groups of 6 rats each, group I was given 2 ml/kg body weight of normal saline for 7 consecutive days and served as the control group, while group II was given 20 mg/kg of 5fluorouracil intraperitone...

PURPOSE To compare the effectiveness of adjuvant chemotherapy regimens in triple negative breast cancer (TNBC) for which no protocol has been determined to be treatment of choice. METHODS In this single-center retrospective trial, we analyzed the adjuvant regimens of 164 TNBC patients among 3253 breast cancer patient records. Adjuvant TAC (docetaxel, doxorubicin, cyclophosphamide), CAF (cyclo...

Based on an animal model to improve the antitumor activity of 5fluorouracil (FUra), a Phase I study of A/-(phosphonacetyl)-i .-aspartate, methotrexate, FUra, and leucovorin was conducted on 44 patients. Meth otrexate was given in an intermediate dose (250 mg/nr) to overcome potential drug resistance, and ¿V-(phosphnnacetyl)-i.-aspartatewas given at a low dose (250 mg/nr') in order to allow esc...

The outcomes for patients with esophageal cancer (EC) underwent standard-dose radical radiotherapy were still disappointing. This phase II study investigated the feasibility, safety and efficacy of radiation dose escalation using simultaneous modulated accelerated radiotherapy (SMART) combined with chemotherapy in 60 EC patients. Radiotherapy consisted of 66Gy at 2.2 Gy/fraction to the gross tu...

We have previously reported on the tumor inhibitory properties of 5-fluorouracil and 5-fluoroorotic acid (3, 4), prepared by Duschinsky et al. (5), and on the initial clinical trials of 5fluorouracil with patients with far advanced solid tumors (6). The metabolism of 5-fluorouracil and 5-fluororotic acid has been studied, data on excretion and tissue distribution in mice and man have been repor...

The plants, Trianthema decandra and Glinus oppositifolius are commonly used by tribal people in India for the treatment of cancer. The anticancer activity of methanol extracts of Trianthema decandra (METD) and Glinus oppositifolius (MEGO) was evaluated in Ehrlich Ascites Carcinoma (EAC) cell line injected intraperitoneally (i.p.) to adult Swiss albino mice at the rate of 2 x106 cells/mouse. The...

The aim of the investigation was to assess the effect of oral 5-flourouracil pre-treatment on the in vitro drug release from a model colon-targeted guar gum matrix tablet formulation of mebendazole. Guar gum matrix tablets of mebendazole were subjected to in vitro drug release studies in simulated colonic fluids (4%w/v of rat caecal contents) obtained after oral treatment of rats either with va...

Pancreatic ductal adenocarcinoma (PDAC) is the fourth cause of cancer-related death in the US, accounting for an estimated 37.000 in 2010 (Jemal et al., 2010). Only about 10-15% of newly diagnosed PDAC are potentially resectable, while the majority of patients present with locally advanced or metastatic cancer. The median survival of non operable patients treated with standard chemotherapy rang...

The anti-tumor activity of the fluorinated uracil derivatives, 5-fluorouracil (FU), 5-fluorouridine (FUR), 5-fluorodeoxyuridine (FUDR), and 5fluoroorotic acid (FO), prepared by Duschinsky, Pleven, Malbica, and Heidelberger (9) 1 have been demonstrated in mice and rats by Heidelberger et al. (11-13). These results have been confirmed and extended by Law (14), Liebling and Humphreys (15), and our...

Hepatic arterial catheters were placed for therapy in 8 patients with primary or metastatic liver cancer. Temporary hepatic ve nous catheters allowed direct sampling of blood for hepatic venous drug concentrations. Patients were administered from three to six infusions at rates of 10, 30, 90, 135, 180, 210, and 270 mg/kg/day (0.053 to 1.43 ¿¿M/kg/min), given over 2 h, of 5fluorouracil (FUra)....