Work supported in part by Agencia Estatal de Investigacion (AEI, Spain) and European Regional Development Fund (ERDF) through project RODIN (PID2019-105717RB-C22), the Catalan administration (AGAUR) under Grant 2017 SGR 578 Fellowship 2020FI B2 00062.

In this paper, we present the realization of a compact, high-power laser system able to excite the ytterbium clock transition at 578 nm. Starting from an external-cavity laser based on a quantum dot chip at 1156 nm with an intra-cavity electro-optic modulator, we were able to obtain up to 60 mW of visible light at 578 nm via frequency doubling. The laser is locked with a 500 kHz bandwidth to an...

Mesoporous ZnO nanoparticles have been synthesized with tremendous increase in specific surface area of up to 578 m(2)/g which was 5.54 m(2)/g in previous reports (J. Phys. Chem. C 113:14676-14680, 2009). Different mesoporous ZnO nanoparticles with average pore sizes ranging from 7.22 to 13.43 nm and specific surface area ranging from 50.41 to 578 m(2)/g were prepared through the sol-gel method...

The RAF kinase family is essential in mediating signal transduction from RAS to ERK. BRAF constitutively active mutations correlate with human cancer development. However, the precise molecular regulation of BRAF activation is not fully understood. Here we report that BRAF is modified by Lys63-linked polyubiquitination at lysine 578 within its kinase domain once it is activated by gain of const...

We identified a new mutation, Asp578Tyr, in alpha-isopropylmalate synthase (a LEU4 gene product) that releases leucine feedback inhibition and causes hyperproduction of isoamyl alcohol (i-AmOH) in sake yeast. Spontaneous sake yeast mutants that express resistance to 5,5,5-trifluoro-DL-leucine (TFL) were isolated, and a mutant strain, TFL20, was characterized at the genetic and biochemical level...

West Nile virus (WNV) has caused outbreaks and sporadic infections in Central, Eastern and Mediterranean Europe for over 45 years. Most strains responsible for the European and Mediterranean basin outbreaks are classified as lineage 1. In recent years, WNV strains belonging to lineage 1 and 2 have been causing outbreaks of neuroinvasive disease in humans in countries such as Italy, Hungary and ...

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The coinage of the Sasanian Empire (224-651 CE) is not only the most important primary source for its monetary and economic history, but also of greatest relevance for its history and art history.Coin hoards are of pivotal importance for studying Sasanian coinage. On August 29,2007,two jars were unearthed during the construction work for the new border sentry post of “Havār-Barxāh-loh” in the P...